Journal Article (Review Article)

DKFZ-2025-02734

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png The evolving landscape of brain metastasis: volume II.

Valiente, M. ; Anders, C. ; Boire, A. ; Izar, B. ; Kotecki, N. ; Malladi, S. ; Massagué, J. ; Moss, N. S. ; Neman, J. ; Preusser, M. ; Schagen, S. ; Siegel, P. M. ; Tawbi, H. ; Venkataramani, V. ; Winkler, F.DKFZ* ; Zadeh, G. ; Joyce, J. A.

2025
Elsevier Amsterdam

Abstract: Brain metastasis (BrM) represents the most common intracranial malignancy, arising in up to 30% of all adult cancer patients and contributing significantly to cancer-related morbidity and mortality. BrM is now recognized as a biologically distinct condition with unique mechanisms of organotropism, colonization, and therapeutic vulnerability. We highlight recent progress in omic and spatial profiling, which has revealed key drivers of brain tropism. These findings have reshaped therapeutic strategies, leading to clinical trials that specifically address central nervous system (CNS) involvement. Emerging approaches now include efforts to prevent brain relapse. Preclinical models increasingly provide sophisticated platforms to evaluate next-generation therapies. Collectively, these advances are transforming the clinical landscape, offering new hope for the prevention and management of BrM through precision medicine and integrated therapeutic strategies.

Keyword(s): brain metastasis ; cancer neuroscience ; neuroimmunology ; precision oncology ; prevention ; tumor microenvironment

Note: epub

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Contributing Institute(s):

1. KKE Neuroonkologie (B320)

Research Program(s):

1. 312 - Funktionelle und strukturelle Genomforschung (POF4-312) (POF4-312)

Appears in the scientific report 2025

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Database coverage:
; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Essential Science Indicators ; IF >= 15 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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