Journal Article

DKFZ-2025-02736

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Microbial metabolites shape mammalian protein translation.

Tuorto, F. ; Lyko, F. (Last author)DKFZ*

2025
Elsevier Amsterdam [u.a.]

Abstract: Eukaryotic queuosine tRNA modification depends on the intake of microbial queuine. In a recent issue of Nature Cell Biology, Zhang et al. show that pre-queuosine 1 (preQ1), an intermediate of the bacterial queuine biosynthesis pathway, competes with queuine for the same mammalian tRNA targets to antagonistically modulate protein translation and cell proliferation.

Keyword(s): Protein Biosynthesis (MeSH) ; RNA, Transfer: metabolism (MeSH) ; Humans (MeSH) ; Animals (MeSH) ; Nucleoside Q: metabolism (MeSH) ; Nucleoside Q: analogs & derivatives (MeSH) ; Nucleoside Q: biosynthesis (MeSH) ; Bacteria: metabolism (MeSH) ; Mammals: metabolism (MeSH) ; RNA, Transfer ; Nucleoside Q

Note: #LA:A130# / DKFZ-ZMBH Alliance / Spotlight

---

Contributing Institute(s):

1. A130 Epigenetik (A130)

Research Program(s):

1. 311 - Zellbiologie und Tumorbiologie (POF4-311) (POF4-311)

Appears in the scientific report 2025

---

Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Essential Science Indicators ; IF >= 25 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

---