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| Home > Publications database > Treating brainstem metastases with stereotactic radiosurgery after whole-brain radiotherapy - Precision strike or risky gamble? |
| Home > Publications database > Treating brainstem metastases with stereotactic radiosurgery after whole-brain radiotherapy - Precision strike or risky gamble? |
| Journal Article | DKFZ-2026-00025 |
; ; ;
2025
Elsevier Science
Amsterdam [u.a.]
Abstract: Stereotactic radiosurgery (SRS) for the management of brainstem metastasis.An 81-year-old female with good performance status (Karnofsky performance status 90%) and a history of metastatic small cell lung cancer to the brain, lung, and pleura presents with a new single brainstem metastasis, measuring 1.27 cm in its largest diameter with a volume of 1.52 cm3 (Fig. 1). The tumor was initially staged as cT4 cN3 cM1a, with lung and pleural metastases. She received first-line chemotherapy with carboplatin and etoposide, achieving a good response. Magnetic resonance imaging six months after the last chemotherapy cycle demonstrated three new brain metastases. She subsequently underwent whole-brain radiotherapy (WBRT), receiving a total dose of 35 Gy delivered in 14 fractions. All brain metastases showed a complete response after the treatment. Her current extracranial disease remains stable after first-line chemotherapy. On physical examination, she has no neurological deficits and denies experiencing new headaches, nausea, or any other new complaints. She is not taking steroids. The brainstem metastasis was diagnosed one year after the completion of WBRT.
Keyword(s): Brain metastasis ; Brainstem metastasis ; Radiosurgery ; Reirradiation ; Stereotactic radiosurgery
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