Journal Article

DKFZ-2026-00183

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Age and sex as risk factors for health-related quality of life outcomes in patients with glioma: a CODAGLIO 2.0 analysis.

Asogwa, O. A. ; Dirven, L. ; Aaronson, N. K. ; Baumert, B. G. ; van den Bent, M. ; Brandes, A. A. ; Clement, P. M. ; Coens, C. ; Chinot, O. ; Gorlia, T. ; Herrlinger, U. ; Hertler, C. ; Keime-Guibert, F. ; Rhun, E. L. ; Lim, L. ; Malmström, A. ; Marosi, C. ; Martinelli, F. ; van der Meulen, M. ; Oliver, K. ; Pace, A. ; Panciroli, C. ; Reijneveld, J. C. ; Renovanz, M. ; Roth, P. ; Seidel, C. ; Stupp, R. ; Wick, W.DKFZ* ; Weller, M. ; Taphoorn, M. J. B. ; Koekkoek, J. A. F.

2026
Oxford University Press Oxford

Abstract: We assessed the clinical relevance of age and sex as risk factors for health-related quality of life (HRQoL) in patients with adult-type diffuse glioma.The CODAGLIO 2.0 database contains 16 randomized trials from 5,369 patients with glioma. Patients' HRQoL was assessed using EORTC QLQ-C30 and QLQ-BN20 questionnaires. In 8 HRQoL scales, we compared mean HRQoL at baseline with the general population and evaluated factors associated with HRQoL over time using linear mixed models (LMMs). We used anchor-based minimally important difference to interpret clinically relevant changes.We included 4,301 patients with baseline HRQoL followed until 3 months. Compared to the general population, patients with glioma at baseline had statistically and clinically relevant worse HRQoL, which was still evident after stratifying by age and sex groups. In LMMs, compared to patients aged ≤60 years, those >60 years had statistically significant associations with worse physical functioning: -2.40 (95% confidence interval (CI) -4.14 to -0.71), better social: 4.88 (2.68 to 7.30) and role: 3.79 (1.39 to 6.16) functioning, and less fatigue: -3.43 (-5.44 to -1.33) and pain: -4.56 (-6.18 to -2.93). Compared to men, women had statistically significant associations with worse physical and social functioning and more fatigue and pain. Associations between age, sex, and HRQoL were not clinically relevant. Performance status had clinically relevant associations in 5/8 scales.Patients with glioma have clinically relevant worse HRQoL compared to the general population. There are statistically but not clinically significant associations between age, sex, and certain HRQoL scales.

Keyword(s): .Brain tumor ; Age ; General population normative data ; Health-related quality of life (HRQoL) ; Sex

Note: epub

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Contributing Institute(s):

1. KKE Neuroonkologie (B320)
2. DKTK HD zentral (HD01)

Research Program(s):

1. 312 - Funktionelle und strukturelle Genomforschung (POF4-312) (POF4-312)

Appears in the scientific report 2026

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Database coverage:
; ; Article Processing Charges ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; DOAJ Seal ; Essential Science Indicators ; Fees ; IF >= 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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