Journal Article (Review Article)

DKFZ-2026-00399

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Needs and health-related quality of life domains relevant to people in Europe with advanced cancer in need of palliative care: a systematic review of qualitative research.

Lizano-Barrantes, C. ; Amat-Fernandez, C. ; Garin, O. ; Luer-Aguila, R. ; Pardo, Y. ; Rojas-Concha, L. ; Thong, M.DKFZ* ; Apolone, G. ; Brunelli, C. ; Caraceni, A. ; Couespel, N. ; Bos, N. ; Groenvold, M. ; Kaasa, S. ; Ciliberto, G. ; Lombardo, C. ; Pietrobon, R. ; Pravettoni, G. ; Sirven, A. ; Vachon, H. ; Gilbert, A. ; Velikova, G. ; Ferrer, M. ; Group, E. W. (Collaboration Author) ; Ciuleanu, T. (Contributor) ; Mitrić, M. (Contributor) ; Ratosa, I. (Contributor) ; Chovanec, M. (Contributor) ; Vieito, M. (Contributor) ; Aguilar, H. (Contributor) ; Ruiz, E. (Contributor) ; Ahlberg, K. (Contributor) ; Simsek, E. T. (Contributor) ; Gumus, M. (Contributor) ; van Braak, I. (Contributor) ; Higgins, C. (Contributor) ; Pinnavaia, L. (Contributor) ; Dantas, C. (Contributor) ; Kalmi, T. (Contributor)

2026
Springer Nature Switzerland AG Cham

Abstract: There is a need for a comprehensive summary of qualitative research on the health-related quality of life (HRQoL) of people with advanced cancer requiring palliative care. We aim to systematically review qualitative studies on outcomes, needs, experiences, preferences, concerns and HRQoL of people in Europe with advanced cancer requiring palliative care over the last decade.Protocol registered ( www.crd.york.ac.uk/PROSPERO , CRD42024575065). The search was conducted in PubMed and Scopus, from 2013 onward.qualitative studies addressing constructs related to the HRQoL of adults with cancer requiring palliative care in Europe. Abstracts and full texts were reviewed, data extracted, and risk of bias assessed independently by two researchers. A thematic analysis stratified by study objective was performed, grouping the emerging themes into categories (primary outcome).Of 18,256 articles identified, 20 fulfilled the inclusion criteria: 10 studies with a generic objective (whole palliative process or end-of-life phase), and 10 with specific focuses. Five categories (35 themes) emerged from the studies with generic focuses: 'Psychological Function' (n = 15), 'Clinical Management' (n = 8), 'Symptoms and Physical Function' (n = 6), 'Social Function' (n = 5), and 'End-of-life' (n = 1). Themes from the 7 studies focusing on treatment, services, and self-management also fitted into these categories, adding 'Spiritual Well-being'.These findings emphasise the predominance of the psychological function domain in cancer patients requiring palliative care, including cancer-related anxiety and distress, coping mechanisms, control and decision-making, and fearing and expecting death. Additionally, clinical management unmet needs were identified in health care, information and communication, and end-of-life settings (home vs. hospital).

Keyword(s): Humans (MeSH) ; Palliative Care: psychology (MeSH) ; Quality of Life: psychology (MeSH) ; Qualitative Research (MeSH) ; Neoplasms: psychology (MeSH) ; Neoplasms: therapy (MeSH) ; Europe (MeSH) ; Cancer ; Neoplasms ; Palliative care ; Qualitative research ; Quality of life ; Systematic review

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Contributing Institute(s):

1. Cancer Survivorship (C071)

Research Program(s):

1. 313 - Krebsrisikofaktoren und Prävention (POF4-313) (POF4-313)

Appears in the scientific report 2026

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Database coverage:
; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Social and Behavioral Sciences ; DEAL Springer ; DEAL Springer ; Ebsco Academic Search ; Essential Science Indicators ; IF < 5 ; JCR ; National-Konsortium ; SCOPUS ; Science Citation Index Expanded ; Social Sciences Citation Index ; Web of Science Core Collection

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