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| Home > Publications database > Repeat resection for recurrent glioblastoma - does timing matter? |
| Journal Article | DKFZ-2026-00451 |
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2026
Springer Science + Business Media B.V
Dordrecht [u.a.]
Abstract: Background: The optimal timing of repeat surgical resection in patients with recurrent IDH-wildtype glioblastoma (rGB)remains unclear. We aimed to characterize temporal patterns between radiological suspicion of recurrence and repeat resection and to evaluate the impact of early versus delayed surgery on the extent of resection (EOR), functional outcomes, adjuvant therapy, and survival.Methods: We retrospectively analyzed a consecutive cohort of 150 patients who underwent resection for histopathologicallyconfirmed rGB between 2015 and 2023 at a single tertiary care center. Assessment of contrast-enhancing preoperative andresidual tumor volumes (RTV on early postoperative MRI) was performed using semi-automated segmentation. Based onthe mean or median time between suspicion of recurrence and repeat resection, patients were stratified into early and latesurgery groups. RANO Resect criteria and a 0.175-ml RTV threshold were used to classify EOR. Functional outcomes,postoperative treatment, as well as progression-free survival (PFS) after repeat resection, and overall survival (OS) aftersuspicion of recurrence were compared between groups.Results: Mean and median time from suspicion of recurrence to repeat resection were 54 and 24 days, respectively, with75% of patients undergoing reoperation within 6 weeks. Applying the mean cut-off, early (n=120) and late (n=30) surgerygroups showed comparable baseline demographics, performance status, tumor eloquence, and preoperative neurologicaldeficits. Preoperative tumor volumes were significantly smaller in the early surgery group (12.7 vs. 25.9 ml, p=0.002). Latesurgery was associated with a trend toward higher RTV and lower rates of gross total resection, though without statisticalsignificance. Rates of transient and permanent postoperative neurological deficits were low (15% and 2%) and did not differbetween groups. Adjuvant treatment patterns differed, with early surgery patients more frequently receiving CCNU-basedchemotherapy, while late surgery patients more often received no further treatment. Median OS after suspicion of recurrence(12.4 vs 14.3 months) and PFS after repeat resection (4 months in both groups) were not significantly different between earlyand late surgery groups. A re-analysis using the median of 24 days as cut-off revealed similar results with regards to survivaland functional outcomes.Conclusion: Most patients with repeat resections for rGB underwent surgery shortly after radiological suspicion of recurrence. While delayed surgery was associated with larger tumor volumes and a trend toward less favorable EOR and adjuvanttreatment, timing of surgery alone was not associated with functional outcomes or survival. These findings support individualized decision-making for repeat resection based on clinical and radiological factors rather than timing alone.
Keyword(s): Pseudo-progression ; Recurrent glioblastoma ; Repeat resection ; Timing of surgery ; Volumetric analysis
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