Journal Article

DKFZ-2026-00711

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Intake of the Total, Classes, and Subclasses of (Poly)phenols and Breast Cancer Risk: A Prospective Analysis of the EPIC Study.

López-Padilla, M. F. ; Seoane-Miraz, D. ; Guiñón-Fort, D. ; Almanza-Aguilera, E. ; Dahm, C. C. ; Louati-Hajji, M. ; Cadeau, C. ; Mancini, F. ; Bajracharya, R.DKFZ* ; Katzke, V.DKFZ* ; Schulze, M. B. ; Masala, G. ; Agnoli, C. ; Signoriello, S. ; Padroni, L. ; Lasheras, C. ; Sánchez, M.-J. ; Aizpurua Atxega, A. ; Colorado-Yohar, S. M. ; Gasque, A. ; Chan, W. C. ; Saleh, Y. M. ; Tjønneland, A. ; Lill, C. M. ; Farràs, M. ; Zamora-Ros, R.

2026
MDPI Basel

Abstract: Polyphenols represent the largest and most diverse class of dietary antioxidants. Epidemiological evidence linking specific (poly)phenol classes, such as flavonoids and lignans, to breast cancer (BC) risk remains limited and largely inconclusive in prospective studies. The aim of this study is to examine the association between the intake of total (poly)phenols-and its classes and subclasses-and BC risk-overall and by subtypes (estrogen, progesterone, and human epidermal growth factor receptor 2 (HER2))-in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. The EPIC cohort includes 257,960 adult women from seven European countries. During a mean follow-up of 14 years, there were 10,722 incident overall BC cases. Associations were computed using Cox regression models adjusted for potential confounders. No significant associations were found between total (poly)phenol intake and overall BC risk (HRQ5 vs. Q1 = 1.02; 95% CI: 0.95-1.11). In addition, null associations were mostly found between classes and subclasses of (poly)phenols and BC subtypes. After stratifying by menopausal status, no significant associations were observed. In conclusion, this study found no evidence of associations between the intake of any class or subclass of (poly)phenols and BC risk in the European population.

Keyword(s): (poly)phenols ; EPIC study ; breast cancer ; cohort ; diet ; flavonoids

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Contributing Institute(s):

1. Epidemiologie von Krebs (C020)

Research Program(s):

1. 313 - Krebsrisikofaktoren und Prävention (POF4-313) (POF4-313)

Appears in the scientific report 2026

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Database coverage:
; ; ; Article Processing Charges ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; DOAJ Seal ; Essential Science Indicators ; Fees ; IF >= 5 ; JCR ; PubMed Central ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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