Journal Article

DKFZ-2026-00721

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png From Anatomy to Outcome: Linking Glioma Location Patterns to Survival Using Non-Negative Matrix Factorization.

Schell, M. ; Kohler, J. ; Folty-Dumitru, M. ; Alzaid, H. ; Pflüger, I. ; Schregel, K. ; Hilgenfeld, T. ; Kernbach, J. ; Krieg, S. ; Sahm, F.DKFZ* ; Wick, W. ; Bendszus, M. ; Jesser, J.

2026
Urban & Vogel München

Abstract: The anatomical distribution of IDH-wildtype gliomas may encode prognostic information not captured by conventional clinical or molecular markers. The purpose of this study was to determine whether continuous, data-driven spatial patterns of tumor involvement provide prognostic value beyond established clinical and molecular factors.We applied non-negative matrix factorization (NMF) to preoperative tumor segmentations from 429 patients with IDH-wildtype gliomas to identify coherent spatial components of tumor involvement. Six reproducible spatial signatures were extracted and integrated into multivariate Cox proportional hazards models. Models additionally included tumor volume, age, sex, O6-methylguanine-DNA methyltransferase (MGMT) promotor methylation status, Eastern Cooperative Oncology Group (ECOG) performance status, and extent of resection.All six spatial patterns demonstrated significant association with overall survival (p ≤ 0.005). Notably, involvement of the left parietal-occipital regions was linked to the poorest outcomes, while temporal patterns showed weaker associations with survival. Incorporating spatial patterns into the prognostic model improved its discriminatory power and altered the influence of tumor volume, indicating an interaction between tumor location and tumor burden.Continuous spatial phenotyping of IDH-wildtype gliomas using NMF captures prognostically relevant information not reflected by conventional markers. Integration of spatial patterns into prognostic models enhances risk stratification and supports the incorporation of detailed spatial analyses into radiologic workflows.

Keyword(s): Brain ; Cox regression ; Glioma ; Imaging biomarkers ; Survival prediction ; Tumor location

Note: epub

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Contributing Institute(s):

1. KKE Neuropathologie (B300)

Research Program(s):

1. 312 - Funktionelle und strukturelle Genomforschung (POF4-312) (POF4-312)

Appears in the scientific report 2026

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Database coverage:
; Clarivate Analytics Master Journal List ; DEAL Springer ; DEAL Springer ; Essential Science Indicators ; IF < 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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