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| Home > Publications database > Diabetes mellitus and health-related quality of life in long-term survivors of breast, colorectal or prostate cancer: a population-based prospective study. |
| Home > Publications database > Diabetes mellitus and health-related quality of life in long-term survivors of breast, colorectal or prostate cancer: a population-based prospective study. |
| Journal Article | DKFZ-2026-01161 |
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2026
Nature Publ. Group
Edinburgh
Abstract: We examined the association between diabetes mellitus (DM) and health-related quality of life (HRQOL) in long-term cancer survivors (LTCS) 14-24 years post-diagnosis, and evaluated the role of DM in the HRQOL of cancer survivors and cancer-free controls.We analysed 6811 LTCS diagnosed with breast, colorectal, or prostate cancer between 1994 and 2004, surveyed in 2008-2011 and 2018-2019, and 1701 controls surveyed in 2013-2014. Multiple linear regression and linear mixed regression models were used to assess cross-sectional and prospective associations of DM and cancer with HRQOL, between participants with and without cancer, and between diabetics and non-diabetics.At baseline, DM prevalence was 14%, and mean age of LTCS with DM was 72 years. LTCS with DM reported consistently poorer HRQOL than non-diabetic counterparts at baseline, with some HRQOL dimensions showing stronger associations with DM than with cancer in cross-sectional analysis. Although cancer generally showed a stronger association with poorer HRQOL than DM, DM was more strongly associated with worse physical functioning, global health status, pain, and appetite loss. The longitudinal perspective revealed similar associations between DM and HRQOL as the cross-sectional perspective for all scales.The findings highlight the need for comprehensive care strategies that address both cancer and DM to enhance health outcomes in diabetic LTCS.
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