Journal Article

DKFZ-2026-01711

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Light-activated insulin receptor modulates neuronal plasticity and cerebellar-driven behavior.

Preissing, B. ; Sackel, F. ; Trajkovic-Arsic, M.DKFZ* ; Rohr, L. ; Linke, A.-L. ; Bewerunge-Hudler, M.DKFZ* ; Liffers, S.-T.DKFZ* ; Siveke, J. T.DKFZ* ; Herlitze, S. ; Siveke, I.

2026
Elsevier St. Louis

Abstract: We have developed an optogenetic tool called InLOV-an insulin receptor fused to a LOV domain-that enables activation of the insulin receptor signaling pathway via light-induced phosphorylation of its intracellular domains. Light activation of InLOV promotes insulin-induced neuronal plasticity in the mouse cerebellum and enhances cerebellar-driven self-motion behavior. Thus, InLOV enables optogenetic modulation of insulin receptor phosphorylation, opening new possibilities for disease modeling and therapeutic strategies for pathological insulin signaling in humans.

Keyword(s): behavior ; cerebellum ; insulin signaling ; neuronal plasticity ; optogenetics

Note: #DKTKZFB26#

---

Contributing Institute(s):

1. DKTK Koordinierungsstelle Essen/Düsseldorf (ED01)
2. Microarrays (W110)
3. DKTK ED Translationale Onkologie Solider Tumore (ED04)

Research Program(s):

1. 319H - Addenda (POF4-319H) (POF4-319H)

Appears in the scientific report 2026

---

Database coverage:
; ; Article Processing Charges ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; DOAJ Seal ; Essential Science Indicators ; Fees ; IF >= 5 ; JCR ; PubMed Central ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

---