Journal Article

DKFZ-2026-02274

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Pancreatic ductal adenocarcinoma: The Vision of Heracles.

Mota Reyes, C.DKFZ* ; Goetz, M. R. ; Algül, H. ; Dogruoez, A. ; Falcomatà, C. ; Gaida, M. M. ; Görgülü, K. ; Gültekin, Y. ; Gürcinar, I. H. ; Hasselluhn, M. C. ; Istvanffy, R. ; Kalluri, R. ; Kalluri, V. S. ; Kiemen, A. ; Kim, P. ; Lee, S.-W. ; Lesina, M. ; Yu, P. ; Maitra, A. ; Müller, C. M. ; Müller, S. ; Nam, D. ; Olive, K. P. ; Pasca Di Magliano, M. ; Rad, R.DKFZ* ; Saur, D. K. M.DKFZ* ; Vander Heiden, M. G. ; Vormehr, M. ; Wood, L. D. ; Yöndem, E. ; Zschäpitz, D. ; Karakas, D. ; Friess, H. ; Ceyhan, G. O. ; Club, E. P. (Collaboration Author) ; Demir, I. E.

2026
Cell Press Cambridge, Mass.

Abstract: Pancreatic ductal adenocarcinoma (PDAC) remains among the deadliest malignancies, as tumors evolve faster than therapies. Resistance is ecological, not merely KRAS driven, involving overlooked players like high-grade pancreatic intraepithelial neoplasias (PanINs), peripancreatic fat, stromal mechanics, myeloid-neural circuits, metabolic rewiring, and systemic host responses. We propose precision interception targeting PanIN/intraductal papillary mucinous neoplasm (IPMN) biology, spatial-functional-proteogenomic classification beyond transcriptomics, the Heracles Protocol (measure, prime, strike, and adapt), and integrated technologies from AI pathology to exosomal delivery and CRISPR-based synergy mapping, together making PDAC more tractable.

Keyword(s): Humans (MeSH) ; Carcinoma, Pancreatic Ductal: genetics (MeSH) ; Carcinoma, Pancreatic Ductal: pathology (MeSH) ; Carcinoma, Pancreatic Ductal: therapy (MeSH) ; Carcinoma, Pancreatic Ductal: drug therapy (MeSH) ; Pancreatic Neoplasms: genetics (MeSH) ; Pancreatic Neoplasms: pathology (MeSH) ; Pancreatic Neoplasms: drug therapy (MeSH) ; Pancreatic Neoplasms: therapy (MeSH) ; Animals (MeSH)

Note: #DKTKZFB26#

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Contributing Institute(s):

1. DKTK Koordinierungsstelle München (MU01)
2. DKTK MU Translationale Krebsforschung (MU05)

Research Program(s):

1. 899 - ohne Topic (POF4-899) (POF4-899)

Appears in the scientific report 2026

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 50 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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