W610
Core Facility Omics IT
Also known as:W610 Core Facility Omics IT; W610 Omics IT and Data Management
| ID | I:(DE-He78)W610-20160331 | 
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Journal Article
 Lin, Y.-Y. (First author)DKFZ* ;  Breuer, K.DKFZ* ;  Weichenhan, D.DKFZ* ;  Lafrenz, P.DKFZ* ;  Sarnataro, A. ;  Wilk, A.DKFZ* ;  Chepeleva, M. ;  Mücke, O.DKFZ* ;  Schönung, M.DKFZ* ;  Petermann, F.DKFZ* ;  Kensche, P. R.DKFZ* ;  Weiser, L.DKFZ* ;  Thommen, F.DKFZ* ;  Giacomelli, G. ;  Nordstroem, K. ;  Gonzalez-Avalos, E. ;  Merkel, A. ;  Kretzmer, H. ;  Fischer, J. ;  Krämer, S.DKFZ* ;  Iskar, M.DKFZ* ;  Wolf, S.DKFZ* ;  Buchhalter, I.DKFZ* ;  Esteller, M. ;  Lawerenz, C. ;  Twardziok, S. ;  Zapatka, M.DKFZ* ;  Hovestadt, V. ;  Schlesner, M. ;  Schulz, M. H. ;  Hoffmann, S. ;  Gerhäuser, C.DKFZ* ;  Walter, J. ;  Hartmann, M.DKFZ* ;  Lipka, D.DKFZ* ;  Assenov, Y. ;  Bock, C. ;  Plass, C.DKFZ* ;  Toth, R. (Last author)DKFZ* ;  Lutsik, P. (Last author)DKFZ*
Pipeline Olympics: continuable benchmarking of computational workflows for DNA methylation sequencing data against an experimental gold standard.
Nucleic acids research 53(19), gkaf970 (2025) [10.1093/nar/gkaf970]2025
  
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Journal Article
 Pfaff, E. (First author)DKFZ* ;  Schramm, K.DKFZ* ;  Blattner-Johnson, M.DKFZ* ;  Jones, B. C.DKFZ* ;  Stark, S.DKFZ* ;  Balasubramanian, G. P.DKFZ* ;  Previti, C.DKFZ* ;  Autry, R. J.DKFZ* ;  Fiesel, P.DKFZ* ;  Sahm, F.DKFZ* ;  Reuss, D.DKFZ* ;  von Deimling, A.DKFZ* ;  van Tilburg, C. M.DKFZ* ;  Pajtler, K. W.DKFZ* ;  Milde, T.DKFZ* ;  Dirksen, U.DKFZ* ;  Kramm, C. M. ;  von Bueren, A. O. ;  Hutter, C. ;  de Wilde, B. ;  Molenaar, J. ;  Gerber, N. U. ;  Lohi, O. ;  Munthe-Kaas, M. C. ;  Georgantzi, K. ;  Kazanowska, B. ;  Zápotocký, M. ;  Kattamis, A. ;  Filippidou, M. ;  Fried, I. ;  Pfister, S. M.DKFZ* ;  Witt, O.DKFZ* ;  Jones, D. (Last author)DKFZ*
Molecular characterization and clinical features of diffuse midline glioma in the pediatric precision oncology registry INFORM.
Acta neuropathologica 150(1), 42 (2025) [10.1007/s00401-025-02945-9]2025
  
 
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Journal Article
 William, D.DKFZ* ;  Bermúdez, M.DKFZ* ;  Kübler, A.DKFZ* ;   et al 
17.6% of patients in a German cohort with exocrine pancreatic cancer were diagnosed with a genetic tumor syndrome—a case for universal genetic testing?
ESMO gastrointestinal oncology 9, 100218 (2025) [10.1016/j.esmogo.2025.100218]2025
  
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Journal Article
 Zou, X. ;  Nie, S. ;  Cao, J. ;  Shi, M. ;  Schuck, K. ;  Shi, Z. ;  Zhang, L. ;  Li, H. ;  Sun, Y. ;  Fang, C. ;  Hu, J. ;  Niu, Y. ;  Yu, Y. ;  Zhang, Z. ;  Li, C. ;  Hu, M. ;  Wang, L. ;  Jiang, K. ;  Lu, Z. ;  Akkan, J. ;  Raulefs, S. ;  Kahlert, C. ;  Roth, S. ;  Herr, I. ;  Wan, Y. ;  Mihaljevic, A. ;  Qian, X. ;  Zhang, Q. ;  Wang, M. H. ;  Kleeff, J. ;  Friess, H. ;  Gu, Z.DKFZ* ;  Michalski, C. W. ;  Shen, S. ;  Kong, B.
ALDH1A3 promotes aggressive basal-like pancreatic cancer through an AP-1/RUNX2 enhancer network.
Oncogene 44(40), 3774-3786 (2025) [10.1038/s41388-025-03530-w]2025
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Journal Article
 Beumer, N. ;  Imbusch, C. D. (First author)DKFZ* ;  Kaufmann, T. ;  Schmidleithner, L. ;  Gütter, K. ;  Stüve, P. ;  Marchel, H. ;  Weichenhan, D.DKFZ* ;  Bähr, M.DKFZ* ;  Ruhland, B. ;  Marini, F. ;  Sanderink, L. ;  Ritter, U. ;  Simon, M.DKFZ* ;  Braband, K. L. ;  Voss, M. M. ;  Helbich, S. S. ;  Mihoc, D. M. ;  Hotz-Wagenblatt, A.DKFZ* ;  Nassabi, H. ;  Eigenberger, A. ;  Prantl, L. ;  Gebhard, C. ;  Rehli, M. ;  Strieder, N. ;  Singh, K. ;  Schmidl, C. ;  Plass, C.DKFZ* ;  Huehn, J. ;  Hehlgans, T. ;  Polansky, J. K. ;  Brors, B. (Last author)DKFZ* ;  Delacher, M. ;  Feuerer, M.
DNA hypomethylation traits define human regulatory T cells in cutaneous tissue and identify their blood recirculating counterparts.
Nature immunology 26(8), 1315-1328 (2025) [10.1038/s41590-025-02210-x]2025
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Journal Article
 Gehrs, S. (First author)DKFZ* ;  Gu, Z. ;  Hey, J.DKFZ* ;  Weichenhan, D.DKFZ* ;  Buckwalter, N.DKFZ* ;  Jakab, M. V.DKFZ* ;  Hotz-Wagenblatt, A.DKFZ* ;  Breuer, K.DKFZ* ;  Prada, M. L.DKFZ* ;  Hübschmann, D.DKFZ* ;  Schlereth, K.DKFZ* ;  Plass, C. (Last author)DKFZ* ;  Augustin, H. (Last author)DKFZ*
DNMT3A-dependent DNA methylation shapes the endothelial enhancer landscape.
Nucleic acids research 53(10), gkaf435 (2025) [10.1093/nar/gkaf435]2025
  
 
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Journal Article
 Betz, A. ;  Huang, H.-E. ;  Gu, Z. ;  Colasanti, O. ;  Li, T.-F. ;  Hesebeck-Brinckmann, J. ;  Gillich, N.DKFZ* ;  Gnouamozi, G. E. ;  Schlesner, M.DKFZ* ;  Vondran, F. W. R. ;  Urban, S. ;  Bartenschlager, R.DKFZ* ;  Binder, M.DKFZ* ;  Lohmann, V.
Reconstitution of interferon regulatory factor 7 expression restores interferon beta induction in Huh7 cells
Journal of virology 99(6), e0070325 (2025) [10.1128/jvi.00703-25]2025
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Journal Article
 Li, T.-F. ;  Rothhaar, P. ;  Lang, A. ;  Grünvogel, O. ;  Colasanti, O. ;  Ugarte, S. M. O. ;  Traut, J. ;  Piras, A. ;  Acosta-Rivero, N. ;  Gonçalves Magalhães, V.DKFZ* ;  Springer, E. ;  Betz, A. ;  Huang, H.-E. ;  Park, J.DKFZ* ;  Qiu, R. ;  Gnouamozi, G. E. ;  Mehnert, A.-K. ;  Thi, V. L. D. ;  Urban, S. ;  Muckenthaler, M. ;  Schlesner, M.DKFZ* ;  Wohlleber, D. ;  Binder, M.DKFZ* ;  Bartenschlager, R.DKFZ* ;  Pichlmair, A. ;  Lohmann, V.
RBM39 shapes innate immunity by controlling the expression of key factors of the interferon response.
Frontiers in immunology 16, 1568056 (2025) [10.3389/fimmu.2025.1568056]2025
  
 
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Journal Article
 Till, A. ;  Siddiqui, R. A. ;  Altbürger, C. ;  Schwarz, R. ;  Huebner, T. ;  Wolf, J. ;  Andres, D. ;  Anker, A. ;  Aretz, S. ;  Haack, T. B. ;  Berlage, T. ;  Beule, D. ;  Boerries, M. ;  Buchhalter, I.DKFZ* ;  Bussmann, J. ;  Engel, C. ;  Friedrichs, J. ;  Fröhling, S.DKFZ* ;  Haenisch, B. ;  Hahne, A. ;  Hübschmann, D.DKFZ* ;  von Kessel, F. ;  Klatt, R. ;  Kreutzfeldt, S.DKFZ* ;  Kron, A. ;  Krude, H. ;  Lübbe, A. ;  Lührig, U. ;  Malek, N. ;  Mertes, C. ;  Möller, Y. ;  Mundlos, C. ;  Nöthen, M. M. ;  Ossowski, S. ;  Pötschke, L. ;  Rasokat, A. ;  Riess, O. ;  Schade, S. ;  Schirmacher, P. ;  Schmutzler, R. ;  Scholl, C. ;  Semler, S. C. ;  Spielmann, M. ;  Stegle, O.DKFZ* ;  Stenzinger, A. ;  Straßburger, J. ;  Schröck, E. ;  Krawczak, M. ;  Kohlbacher, O.
Germany's national genomDE strategy.
Nature medicine nn, nn (2025) [10.1038/s41591-025-03991-2]2025
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Journal Article
 Volkmar, M. (First author)DKFZ* ;  Hoser, D.Extern* ;  Lauenstein, C.DKFZ* ;  Rebmann, J. ;  Hotz-Wagenblatt, A.DKFZ* ;  Rieger, J. H.DKFZ* ;  Poschke, I.DKFZ* ;  Becker, J.DKFZ* ;  Riemer, A. B.DKFZ* ;  Sprick, M.DKFZ* ;  Trumpp, A.DKFZ* ;  Strobel, O. ;  Blankenstein, T. ;  Willimsky, G.DKFZ* ;  Offringa, R. (Last author)DKFZ*
Enhanced mutanome analysis towards the induction of neoepitope-reactive T-cell responses for personalized immunotherapy of pancreatic cancer.
Journal for ImmunoTherapy of Cancer 13(6), e011802 (2025) [10.1136/jitc-2025-011802]2025
  
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All known publications ...
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