Journal Article

DKFZ-2026-00450

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Managing Workflow Executions with WESkit.

Schneider-Lunitz, V. ; Kensche, P. (First author)DKFZ* ; Kraatz, L. ; Strubel, P. ; Borufka, S.DKFZ* ; Parala, G.DKFZ* ; Kanitz, A. ; Eils, R. ; Buchhalter, I.DKFZ* ; Twardziok, S. O.

2026
Oxford Univ. Press Oxford

Abstract: In biomedical research, managing computational workflows across numerous projects-with varying parameters, tools, and environments-creates major challenges in scalability, reproducibility, and collaboration. Here we present WESkit, an implementation of the Global Alliance for Genomics and Health (GA4GH) Workflow Execution Service (WES) interface, designed to streamline the execution, monitoring, and documentation of data processing workflows. It addresses the complexities involved in managing numerous executions with varying parameters across diverse research projects. Supporting both Snakemake and Nextflow, the system enables consistent automation and centralized monitoring, which benefits research groups aiming for long-term reproducibility and scalable collaboration. Its suitability for larger teams and service units is further enhanced by seamless integration into cloud environments, contributing to the GA4GH cloud framework.The software WESkit is available under MIT license at the GitLab repository (https://gitlab.com/one-touch-pipeline/weskit).The WESkit main repository is archived at Software Heritage (https://archive.softwareheritage.org/browse/origin/directory/? origin_url=https://gitlab.com/one-touch-pipeline/weskit/api.git) and can be found using 'one-touch-pipeline/weskit' term in the search section.Supplementary data are available at Bioinformatics online.

Note: #EA:W610# / 2026 Feb 28;42(3):btag091

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Contributing Institute(s):

1. Core Facility Omics IT (W610)

Research Program(s):

1. 319H - Addenda (POF4-319H) (POF4-319H)

Appears in the scientific report 2026

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Database coverage:
; ; ; ; Article Processing Charges ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; DOAJ Seal ; Ebsco Academic Search ; Essential Science Indicators ; Fees ; IF >= 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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