Journal Article (Editorial)

DKFZ-2020-00162

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png The heat's on: nuclear stress bodies signal intron retention.

Erhardt, S. ; Stoecklin, G.

2020
Wiley Hoboken, NJ [u.a.]

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Please use a persistent id in citations: doi:10.15252/embj.2019104154

Abstract: The cellular response to heat shock requires massive adaptation of gene expression driven by the transcription factor HSF1, which assembles in nuclear stress bodies together with human satellite III RNA and numerous splicing factors. In this issue of The EMBO Journal, Ninomiya et al demonstrate that nuclear stress bodies serve as a platform for phosphorylation of the SR protein SRSF9 by the CLK1 kinase, which promotes retention of a large number of introns during the recovery phase from heat shock.

Note: DKFZ-ZMBH Alliance2020 Feb 3;39(3):e104154

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Contributing Institute(s):

1. Posttranskriptionelle Genregulation (A200)

Research Program(s):

1. 311 - Signalling pathways, cell and tumor biology (POF3-311) (POF3-311)

Appears in the scientific report 2020

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Database coverage:
; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; IF >= 10 ; JCR ; NCBI Molecular Biology Database ; PubMed Central ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Web of Science Core Collection

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