Journal Article

DKFZ-2021-02192

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Local ablative treatment with surgery and/or radiotherapy in single-site and oligometastatic carcinoma of unknown primary.

Pouyiourou, M. (First author)DKFZ* ; Wohlfromm, T.DKFZ* ; Kraft, B.DKFZ* ; Hielscher, T.DKFZ* ; Stichel, D. ; von Deimling, A. ; Delorme, S.DKFZ* ; Endris, V. ; Neumann, O. ; Stenzinger, A. ; Krämer, A.DKFZ* ; Bochtler, T. (Last author)DKFZ*

2021
Elsevier Amsterdam [u.a.]

Abstract: Single-site carcinoma of unknown primary (CUP) is recognised as a distinct favourable subtype in the European Society of Medical Oncology (ESMO) classification. There is broad consensus that these patients are candidates for local ablative treatment strategies with surgery and/or radiotherapy, but data on their outcomes are scarce.In this study, we have addressed the prospects of cure and prognostic factors in a retrospective cohort of 63 patients who were eligible for local treatment at our centre.Median event-free (EFS) and overall survival (OS) were 15.6 months and 52.5 months, respectively. Of 61 patients who received local treatment, 20 (32.8%) remained event-free over a median follow-up of 28 months. Baseline clinical parameters including affected organ, number, volume and histology of metastases had no significant impact on prognosis, whereas deleterious TP53 mutations and DNA copy number loss emerged as independent adverse risk factors with respect to EFS. Surgical treatment was associated with improved OS as compared to radiation-based therapy.Our study advocates to pursue localised treatment with surgery and/or radiotherapy whenever feasible and implies that genetic parameters might additionally determine the clinical course of single-site CUP patients.

Keyword(s): CUP (cancer of unknown primary) ; Copy number loss ; Oligometastasis ; Prognosis ; Radiotherapy ; Single metastatic deposit ; Surgery ; TP53

Note: #EA:A360#LA:A360#

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Contributing Institute(s):

1. KKE Mol. Hämatologie/Onkologie (A360)
2. C060 Biostatistik (C060)
3. E010 Radiologie (E010)

Research Program(s):

1. 311 - Zellbiologie und Tumorbiologie (POF4-311) (POF4-311)

Appears in the scientific report 2021

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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