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| Home > Publications database > Investigating water radiolysis during proton mini and micro beam irradiation with TOPAS-nBio |
| Home > Publications database > Investigating water radiolysis during proton mini and micro beam irradiation with TOPAS-nBio |
| Conference Presentation (Invited) | DKFZ-2021-02539 |
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2021
Abstract: Authors: Celine Karle, Lucas Noberto Burigo, Riccardo Dal Bello, Joao SecoThe main focus of this project is to assess the chemical products of water radiolysis during proton mini and micro beams irradiation with TOPAS-nbio. Mini and micro beams are characterized by the alternation of high dose peaks and low dose valleys. The peak to valley distance commonly used is either millimeter or micrometer for mini or micro beam respectively. Molecular candidates, such as H2O2, are currently being investigated in order to potentially explain the mechanisms of this radiation therapy form.TOPAS-nbio is an extension of the TOPAS software to adjust it to radiobiological applications. Therefore, the MC simulation can be used to model the temporal production, interaction and diffusion of different radiolysis products. Firstly, a single proton beam, which irradiates a water phantom, is modeled. The produced chemical species during the pre-chemical and chemical state up to 1 µs are scored. The temporal change of the distribution of the molecules H2O2and HO2 of special interest since they reach a steady state after 1 µs, which could potentially explain the efficiency of micro and mini-beam radiation therapy.The steady-state conclusion has previously been drawn by the TRAX-CHEM simulation [Dal Bello, R., et al. (2020). Proposal of a Chemical Mechanism for Mini-Beam and Micro-Beam Efficacy, https://doi.org/10.3389/fphy.2020.564836]. To verify this finding, the temporal evolution of the relative abundance from the mentioned molecules and the H2O2 distribution with increasing distance from the beam axis is investigated with the TOPAS-nbio software and compared to the TRAX-CHEM results.
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