Journal Article

DKFZ-2022-00151

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Reproductive factors do not influence survival with ovarian cancer.

Phung, M. T. ; Alimujiang, A. ; Berchuck, A. ; Anton-Cluver, H. ; Schildkraut, J. M. ; Bandera, E. V. ; Chang-Claude, J.DKFZ* ; Chase, A. ; Doherty, J. A. ; Grout, B. ; Goodman, M. T. ; Hanley, G. E. ; Lee, A. W. ; McKinnon Deurloo, C. ; Menon, U. ; Modugno, F. ; Pharoah, P. D. P. ; Pike, M. C. ; Richardson, J. ; Risch, H. A. ; Sieh, W. ; Terry, K. L. ; Webb, P. M. ; Wentzensen, N. ; Wu, A. H. ; Pearce, C. L.

2022
AACR Philadelphia, Pa.

This record in other databases:  

Please use a persistent id in citations: doi:10.1158/1055-9965.EPI-21-1091

Abstract: Background Previous studies on the association between reproductive factors and ovarian cancer survival are equivocal, possibly due to small sample sizes. Methods Using data on 11,175 people diagnosed with primary invasive epithelial ovarian, fallopian tube, or primary peritoneal cancer (ovarian cancer) from 16 studies in the Ovarian Cancer Association Consortium (OCAC), we examined the associations between survival and age at menarche, combined oral contraceptive use, parity, breastfeeding, age at last pregnancy, and menopausal status using Cox proportional hazard models. The models were adjusted for age at diagnosis, race/ethnicity, education level, and OCAC study and stratified on stage and histotype. Results During the mean follow-up of 6.34 years (SD=4.80), 6,418 patients passed away (57.4%). There was no evidence of associations between the reproductive factors and survival among ovarian cancer patients overall or by histotype. Conclusions This study found no association between reproductive factors and survival after an ovarian cancer diagnosis. Impact Reproductive factors are well-established risk factors for ovarian cancer, but they are not associated with survival after a diagnosis of ovarian cancer.

Note: 2022 Apr 1;31(4):909-913

---

Contributing Institute(s):

1. C020 Epidemiologie von Krebs (C020)

Research Program(s):

1. 313 - Krebsrisikofaktoren und Prävention (POF4-313) (POF4-313)

Appears in the scientific report 2022

---

Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; Essential Science Indicators ; IF < 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

---