Journal Article (Review Article)

DKFZ-2023-00231

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Updates on the WHO diagnosis of IDH-mutant glioma.

Reuss, D. E. (Last author)DKFZ*

2023
Springer Science + Business Media B.V Dordrecht [u.a.]

This record in other databases:  

Please use a persistent id in citations: doi:10.1007/s11060-023-04250-5

Abstract: The WHO classification of Tumors of the Central Nervous System represents the international standard classification for brain tumors. In 2021 the 5th edition (WHO CNS5) was published, and this review summarizes the changes regarding IDH-mutant gliomas and discusses unsolved issues and future perspectives.This review is based on the 5th edition of the WHO Blue Book of CNS tumors (WHO CNS5) and relevant related papers.Major changes include taxonomy and nomenclature of IDH-mutant gliomas. Essential and desirable criteria for classification were established considering technical developments. For the first time molecular features are not only relevant for the classification of IDH-mutant gliomas but may impact grading as well.WHO CNS5 classification moves forward towards a classification which is founded on tumor biology and serves clinical needs. The rapidly increasing knowledge on the molecular landscape of IDH-mutant gliomas is expected to further refine classification and grading in the future.

Keyword(s): CNS5 ; Classification ; Glioma ; IDH-mutant ; Molecular pathology ; Neuropathology ; WHO

Note: #LA:B300# / 2023 May;162(3):461-469

---

Contributing Institute(s):

1. KKE Neuropathologie (B300)
2. DKTK HD zentral (HD01)

Research Program(s):

1. 312 - Funktionelle und strukturelle Genomforschung (POF4-312) (POF4-312)

Appears in the scientific report 2023

---

Database coverage:
; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; DEAL Springer ; DEAL Springer ; Essential Science Indicators ; IF < 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

---