Journal Article

DKFZ-2023-01202

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Surface Chemistry and Specific Surface Area rule the Efficiency of Gold Nanoparticle Sensitizers in Proton Therapy.

Johny, J. ; van Halteren, C. E. R. ; Cakir, F.-C. ; Zwiehoff, S. ; Behrends, C. ; Bäumer, C.DKFZ* ; Timmermann, B.DKFZ* ; Rauschenbach, L.DKFZ* ; Tippelt, S. ; Scheffler, B.DKFZ* ; Schramm, A. ; Rehbock, C. ; Barcikowski, S.

2023
Wiley-VCH Weinheim

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Please use a persistent id in citations: doi:10.1002/chem.202301260

Abstract: Gold nanoparticles (AuNPs) are known radiosensitizers in proton therapy (PT) applicable for the treatment of solid tumors, where they amplify production of reactive oxygen species (ROS). However, it is underexplored how this amplification is correlated with the AuNPs´ surface chemistry. To clarify this issue, we fabricated ligand-free AuNPs of different mean diameters by laser ablation in liquids (LAL) and laser fragmentation in liquids (LFL) and irradiated them with clinically relevant proton fields using water phantoms. ROS generation was monitored by the fluorescent dye 7-OH-coumarin. Our findings reveal an enhancement of ROS production driven by I) increased total particle surface area, II) utilization of ligand-free AuNPs avoiding sodium citrate as a radical quencher ligands, and III) a higher density of structural defects generated by LFL synthesis, indicated by surface charge density. Based on these findings it may be concluded that the surface chemistry is a major and underexplored contributor to ROS generation and sensitizing effects of AuNPs in PT. We further highlight the applicability of AuNPs in vitro in human medulloblastoma cells.

Keyword(s): clinical irradiation dose ; gold nanoparticle colloid ; hydroxyl radicals ; laser processing in liquids ; proton radiotherapy

Note: 2023 Sep 6;29(50):e202301260

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Contributing Institute(s):

1. DKTK Koordinierungsstelle Essen/Düsseldorf (ED01)

Research Program(s):

1. 899 - ohne Topic (POF4-899) (POF4-899)

Appears in the scientific report 2023

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Database coverage:
; Chemical Reactions ; Clarivate Analytics Master Journal List ; Current Contents - Physical, Chemical and Earth Sciences ; DEAL Wiley ; Ebsco Academic Search ; Essential Science Indicators ; IF < 5 ; Index Chemicus ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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