Journal Article

DKFZ-2023-02029

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Dietary amino acids and risk of stroke subtypes: a prospective analysis of 356,000 participants in seven European countries.

Tong, T. Y. N. ; Clarke, R. ; Schmidt, J. A. ; Huybrechts, I. ; Noor, U. ; Forouhi, N. G. ; Imamura, F. ; Travis, R. C. ; Weiderpass, E. ; Aleksandrova, K. ; Dahm, C. C. ; van der Schouw, Y. T. ; Overvad, K. ; Kyrø, C. ; Tjønneland, A. ; Kaaks, R.DKFZ* ; Katzke, V.DKFZ* ; Schiborn, C. ; Schulze, M. B. ; Mayen-Chacon, A.-L. ; Masala, G. ; Sieri, S. ; de Magistris, M. S. ; Tumino, R. ; Sacerdote, C. ; Boer, J. M. A. ; Verschuren, W. M. M. ; Brustad, M. ; Nøst, T. H. ; Crous-Bou, M. ; Petrova, D. ; Amiano, P. ; Huerta, J. M. ; Moreno-Iribas, C. ; Engström, G. ; Melander, O. ; Johansson, K. ; Lindvall, K. ; Aglago, E. K. ; Heath, A. K. ; Butterworth, A. S. ; Danesh, J. ; Key, T. J.

2024
Springer Heidelberg

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Please use a persistent id in citations: doi:10.1007/s00394-023-03251-4

Abstract: Previously reported associations of protein-rich foods with stroke subtypes have prompted interest in the assessment of individual amino acids. We examined the associations of dietary amino acids with risks of ischaemic and haemorrhagic stroke in the EPIC study.We analysed data from 356,142 participants from seven European countries. Dietary intakes of 19 individual amino acids were assessed using validated country-specific dietary questionnaires, calibrated using additional 24-h dietary recalls. Multivariable-adjusted Cox regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) of ischaemic and haemorrhagic stroke in relation to the intake of each amino acid. The role of blood pressure as a potential mechanism was assessed in 267,642 (75%) participants.After a median follow-up of 12.9 years, 4295 participants had an ischaemic stroke and 1375 participants had a haemorrhagic stroke. After correction for multiple testing, a higher intake of proline (as a percent of total protein) was associated with a 12% lower risk of ischaemic stroke (HR per 1 SD higher intake 0.88; 95% CI 0.82, 0.94). The association persisted after mutual adjustment for all other amino acids, systolic and diastolic blood pressure. The inverse associations of isoleucine, leucine, valine, phenylalanine, threonine, tryptophan, glutamic acid, serine and tyrosine with ischaemic stroke were each attenuated with adjustment for proline intake. For haemorrhagic stroke, no statistically significant associations were observed in the continuous analyses after correcting for multiple testing.Higher proline intake may be associated with a lower risk of ischaemic stroke, independent of other dietary amino acids and blood pressure.

Keyword(s): Amino acids ; Dietary protein ; Haemorrhagic stroke ; Ischaemic stroke ; Nutritional epidemiology ; Prospective cohort

Note: 2024 Feb;63(1):209-220

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Contributing Institute(s):

1. C020 Epidemiologie von Krebs (C020)

Research Program(s):

1. 313 - Krebsrisikofaktoren und Prävention (POF4-313) (POF4-313)

Appears in the scientific report 2023

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Agriculture, Biology and Environmental Sciences ; DEAL Springer ; DEAL Springer ; Ebsco Academic Search ; Essential Science Indicators ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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