Journal Article

DKFZ-2023-02225

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Therapeutic drug monitoring of osimertinib in non-small cell lung cancer and short bowel syndrome: A case report.

Longuespée, R. (First author)DKFZ* ; Kunz, J. ; Fresnais, M. ; Foerster, K. I. ; Burhenne, J. ; Thomas, M. ; Kazdal, D. ; Stenzinger, A. ; Christopoulos, P. ; Haefeli, W. E.

2024
Wiley-Blackwell Oxford

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Please use a persistent id in citations: doi:10.1111/bcp.15924

Abstract: Short bowel syndrome (SBS) following extensive intestinal resection is often characterized by impaired absorption of orally administered drugs, including tyrosine kinase inhibitors (TKI). We report the case of a patient with EGFR-mutated non-small cell lung carcinoma treated with 80 mg/day of the TKI osimertinib who achieved partial response of the tumour, but was subsequently subjected to a double-barrelled jejunostomy due to ileus. Due to the development of SBS after the bypass surgery, plasma concentrations of osimertinib were monitored using mass spectrometry. The therapeutic drug monitoring confirmed a malabsorption of osimertinib in the patient (108 ng/mL, which is below the 5th percentile of the expected plasma concentration) and was useful to guide adjustments of TKI dosing in order to achieve adequate blood levels (161 ng/mL after increase of the dose to 120 mg/day) in order to maintain tumour control.

Keyword(s): LC-MS/MS ; MALDI-MS/MS ; non-small cell lung cancer ; osimertinib ; short bowel syndrome ; therapeutic drug monitoring

Note: Case report / 2024 Jan;90(1):344-349 / #EA:B350#

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Contributing Institute(s):

1. Metabolischer Crosstalk bei Krebserkrankungen (B350)

Research Program(s):

1. 312 - Funktionelle und strukturelle Genomforschung (POF4-312) (POF4-312)

Appears in the scientific report 2023

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; DEAL Wiley ; Ebsco Academic Search ; Essential Science Indicators ; IF < 5 ; JCR ; PubMed Central ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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