Journal Article (Review Article)

DKFZ-2024-00622

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png The Complex Role of Infectious Agents in Human Cutaneous T-Cell Lymphoma Pathogenesis: From Candidate Etiological Factors to Potential Therapeutics.

Angelova, A. L. (First author)DKFZ* ; Rommelaere, J.DKFZ* ; Ungerechts, G. (Last author)DKFZ*

2024
MDPI Basel

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Please use a persistent id in citations: doi:10.3390/pathogens13030184

Abstract: Cutaneous T-cell lymphoma (CTCL) is a devastating, potentially fatal T-lymphocyte malignancy affecting the skin. Despite all efforts, the etiology of this disease remains unknown. Infectious agents have long been suspected as factors or co-factors in CTCL pathogenesis. This review deals with the panel of bacterial and viral pathogens that have been investigated so far in an attempt to establish a potential link between infection/carriage and CTCL development. A special focus is given to a recently discovered human protoparvovirus, namely the cutavirus (CutaV), which has emerged as a plausible CTCL etiological agent. Available evidence in support of this hypothesis as well as alternative interpretations and uncertainties raised by some conflicting data are discussed. The complexity and multifacetedness of the Parvoviridae family of viruses are illustrated by presenting another protoparvovirus, the rat H-1 parvovirus (H-1PV). H-1PV belongs to the same genus as the CutaV but carries considerable potential for therapeutic applications in cutaneous lymphoma.

Keyword(s): Parvoviridae ; cutaneous T-cell lymphoma ; cutavirus ; infectious etiology ; oncolytic H-1 parvovirus

Note: #EA:F230#LA:F230# / NEU #EA:D490#LA:D490#

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Contributing Institute(s):

1. KKE Virotherapie (F230)
2. KKE Virotherapie (D490)

Research Program(s):

1. 314 - Immunologie und Krebs (POF4-314) (POF4-314)

Appears in the scientific report 2024

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