Journal Article

DKFZ-2024-00836

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png The underestimated preventive effects of flexible sigmoidoscopy screening: re-analysis and meta-analysis of randomized trials.

Brenner, H. (First author)DKFZ* ; Heisser, T.DKFZ* ; Cardoso, R.DKFZ* ; Hoffmeister, M. (Last author)DKFZ*

2024
Springer Science + Business Media B.V. Dordrecht [u.a.]

This record in other databases:  

Please use a persistent id in citations: doi:10.1007/s10654-024-01120-w

Abstract: Flexible sigmoidoscopy (FS), which is less invasive, resource intensive and costly than colonoscopy, is among the recommended screening options for colorectal cancer (CRC). Four large randomized trials consistently reported statistically significant, albeit modest effects of screening by FS on CRC incidence. However, their effect estimates included cancers that were already prevalent at recruitment and could not have been prevented by screening. We performed a re-analysis and meta-analysis of two of the trials (including the largest one) to estimate reduction of truly incident cases by a single FS offered between 55 and 64 years of age among the 'at risk study population' without prevalent CRC at recruitment. In meta-analyses of data reported after more than 15 years of follow-up, relative risk (95% CI) in intention-to-screen and per-protocol analyses were 0.71 (0.66-0.76) and 0.59 (0.55-0.65) for any CRC, and 0.52 (0.47-0.57) and 0.34 (0.30-0.39) for distal CRC, respectively. These results indicate much stronger effects than those suggested by the original reports and imply that a single screening FS can prevent approximately two out of three distal incident CRC cases within 15 + years of follow-up.

Keyword(s): Colorectal cancer ; Flexible sigmoidoscopy ; Incidence ; Risk ; Screening ; Trials

Note: #EA:C070#LA:C070# / 2024 Jul;39(7):743-751

---

Contributing Institute(s):

1. C070 Klinische Epidemiologie und Alternf. (C070)
2. DKTK HD zentral (HD01)

Research Program(s):

1. 313 - Krebsrisikofaktoren und Prävention (POF4-313) (POF4-313)

Appears in the scientific report 2024

---

Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; DEAL Springer ; DEAL Springer ; Essential Science Indicators ; IF >= 10 ; JCR ; National-Konsortium ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

---