Journal Article

DKFZ-2024-02172

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Potential of pre-diagnostic metabolomics for colorectal cancer risk assessment or early detection.

Seum, T. (First author)DKFZ* ; Frick, C.DKFZ* ; Cardoso, R.DKFZ* ; Bhardwaj, M.DKFZ* ; Hoffmeister, M.DKFZ* ; Brenner, H. (Last author)DKFZ*

2024
Springer Nature [London]

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Please use a persistent id in citations: doi:10.1038/s41698-024-00732-5

Abstract: This systematic review investigates the efficacy of metabolite biomarkers for risk assessment or early detection of colorectal cancer (CRC) and its precursors, focusing on pre-diagnostic biospecimens. Searches in PubMed, Web of Science, and SCOPUS through December 2023 identified relevant prospective studies. Relevant data were extracted, and the risk of bias was assessed with the QUADAS-2 tool. Among the 26 studies included, significant heterogeneity existed for case numbers, metabolite identification, and validation approaches. Thirteen studies evaluated individual metabolites, mainly lipids, while eleven studies derived metabolite panels, and two studies did both. Nine panels were internally validated, resulting in an area under the curve (AUC) ranging from 0.69 to 0.95 for CRC precursors and 0.72 to 1.0 for CRC. External validation was limited to one panel (AUC = 0.72). Metabolite panels and lipid-based biomarkers show promise for CRC risk assessment and early detection but require standardization and extensive validation for clinical use.

Note: #EA:C070#LA:C070#

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Contributing Institute(s):

1. C070 Klinische Epidemiologie und Alternf. (C070)
2. DKTK HD zentral (HD01)

Research Program(s):

1. 313 - Krebsrisikofaktoren und Prävention (POF4-313) (POF4-313)

Appears in the scientific report 2024

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Database coverage:
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