Journal Article (Review Article)

DKFZ-2025-00116

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Cancer Neuroscience of Brain Tumors: From Multicellular Networks to Neuroscience-Instructed Cancer Therapies.

Venkataramani, V. (First author)DKFZ* ; Yang, Y.DKFZ* ; Ille, S. ; Suchorska, B. ; Loges, S.DKFZ* ; Tost, H. ; Sahm, F.DKFZ* ; Pfister, S.DKFZ* ; Trumpp, A.DKFZ* ; Krieg, S. M. ; Kuner, T. ; Wick, W.DKFZ* ; Winkler, F. (Last author)DKFZ*

2025
[Verlag nicht ermittelbar] Philadelphia, Pa.

This record in other databases:  

Please use a persistent id in citations: doi:10.1158/2159-8290.CD-24-0194

Abstract: Deepening our understanding of neuro-cancer interactions can innovate brain tumor treatment. This mini review unfolds the most relevant and recent insights into the neural mechanisms contributing to brain tumor initiation, progression, and resistance, including synaptic connections between neurons and cancer cells, paracrine neuro-cancer signaling, and cancer cells' intrinsic neural properties. We explain the basic and clinical-translational relevance of these findings, identify unresolved questions and particularly interesting future research avenues, such as central nervous system neuro-immunooncology, and discuss the potential transferability to extracranial cancers. Lastly, we conceptualize ways toward clinical trials and develop a roadmap toward neuroscience-instructed brain tumor therapies. Significance: Neural influences on brain tumors drive their growth and invasion. Herein, we develop a roadmap to use these fundamentally new insights into brain tumor biology for improved outcomes.

Keyword(s): Humans (MeSH) ; Brain Neoplasms: pathology (MeSH) ; Animals (MeSH) ; Neurosciences (MeSH)

Note: DKFZ-ZMBH Alliance / #EA:B320#LA:B320#

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Contributing Institute(s):

1. KKE Neuroonkologie (B320)
2. DKTK HD zentral (HD01)
3. Personalisierte Medizinische Onkologie (A420)
4. KKE Neuropathologie (B300)
5. B062 Pädiatrische Neuroonkologie (B062)
6. A010 Stammzellen und Krebs (A010)

Research Program(s):

1. 312 - Funktionelle und strukturelle Genomforschung (POF4-312) (POF4-312)

Appears in the scientific report 2025

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Essential Science Indicators ; IF >= 25 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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