Journal Article

DKFZ-2025-00252

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Serially Quantifying TERT Rearrangement Breakpoints in ctDNA Enables Minimal Residual Disease Monitoring in Patients with Neuroblastoma.

Hollander, J. F. ; Szymansky, A. ; Wünschel, J. ; Astrahantseff, K. ; Rosswog, C. ; Thorwarth, A. ; Thole-Kliesch, T. M. ; Chamorro González, R. ; Hundsdörfer, P. ; Hauptmann, K. ; Schmelz, K. ; Gürgen, D. ; Rogasch, J. M. M. ; Henssen, A. G. ; Fischer, M. ; Schulte, J.DKFZ* ; Eckert, C.Extern* ; Eggert, A.DKFZ* ; Lodrini, M. ; Deubzer, H. E.DKFZ*

2025
American Association for Cancer Research Philadelphia, Pa.

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Please use a persistent id in citations: doi:10.1158/2767-9764.CRC-24-0569

Abstract: Real-time molecular monitoring of TERT-rearranged high-risk neuroblastoma is an unmet clinical need. We tested liquid biopsy-based assays for patient-individualized TERT breakpoint sequences to monitor disease in pediatric patients. Our digital PCR approach provides high resolution of spatial and temporal disease quantification in individual patients and is applicable for clinical routine.

Keyword(s): Humans (MeSH) ; Neuroblastoma: genetics (MeSH) ; Neuroblastoma: pathology (MeSH) ; Telomerase: genetics (MeSH) ; Neoplasm, Residual: genetics (MeSH) ; Gene Rearrangement: genetics (MeSH) ; Circulating Tumor DNA: genetics (MeSH) ; Circulating Tumor DNA: blood (MeSH) ; Liquid Biopsy: methods (MeSH) ; Biomarkers, Tumor: genetics (MeSH) ; Biomarkers, Tumor: blood (MeSH) ; Child (MeSH) ; Child, Preschool (MeSH) ; Male (MeSH) ; Telomerase ; TERT protein, human ; Circulating Tumor DNA ; Biomarkers, Tumor

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Contributing Institute(s):

1. DKTK Koordinierungsstelle Berlin (BE01)

Research Program(s):

1. 899 - ohne Topic (POF4-899) (POF4-899)

Appears in the scientific report 2025

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