Journal Article (Review Article)

DKFZ-2025-01276

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Gastric cancer: from biomarkers to functional precision medicine.

Albrecht, P. (First author)DKFZ* ; Karabati, E.DKFZ* ; Ebert, M. P. ; Betge, J. (Last author)DKFZ*

2025
Elsevier Science Amsterdam [u.a.]

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Please use a persistent id in citations: doi:10.1016/j.molmed.2025.05.007

Abstract: Gastric cancer (GC) remains a deadly disease because of late detection and limited treatment options at advanced stages. Treatment of patients with metastatic disease is based on chemotherapy, complemented by antibodies targeting HER2, VEGFR2, and more recently PD-1 or claudin 18.2. Further targets, such as FGFR2b, as well as novel drug classes including antibody-drug conjugates (ADCs) and bispecific antibodies, are promising developments in GC treatment. Despite the failure of several targeted agents, the landscape of GC therapy is evolving rapidly, facilitated by umbrella or platform precision medicine trials. The integration of next-generation sequencing and other omics techniques into molecular tumor boards, as well as functional drug testing on patient-derived models, might bring us closer to personalized oncology and ultimately improve patient survival.

Keyword(s): functional precision medicine ; gastroesophageal adenocarcinoma ; immunotherapy ; patient-derived organoids ; precision oncology ; targeted therapy

Note: #EA:B440#LA:B440# / 2025 Dec;31(12):1089-1102

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Contributing Institute(s):

1. NWG-KKE Translationale Gastrointestinale Onkologie und präklinische Modelle (B440)
2. DKTK HD zentral (HD01)

Research Program(s):

1. 312 - Funktionelle und strukturelle Genomforschung (POF4-312) (POF4-312)

Appears in the scientific report 2025

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Database coverage:
; BIOSIS Previews ; BIOSIS Reviews Reports And Meetings ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 10 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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