Journal Article (Review Article)

DKFZ-2025-02507

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png The many faces of H3.3 in regulating chromatin in embryonic stem cells and beyond.

Cohen, L. R. Z. ; Meshorer, E.

2024
Elsevier Science Amsterdam [u.a.]

Abstract: H3.3 is a highly conserved nonreplicative histone variant. H3.3 is enriched in promoters and enhancers of active genes, but it is also found within suppressed heterochromatin, mostly around telomeres. Accordingly, H3.3 is associated with seemingly contradicting functions: It is involved in development, differentiation, reprogramming, and cell fate, as well as in heterochromatin formation and maintenance, and the silencing of developmental genes. The emerging view is that different cellular contexts and histone modifications can promote opposing functions for H3.3. Here, we aim to provide an update with a focus on H3.3 functions in early mammalian development, considering the context of embryonic stem cell maintenance and differentiation, to finally conclude with emerging roles in cancer development and cell fate transition and maintenance.

Keyword(s): Histones: metabolism (MeSH) ; Humans (MeSH) ; Animals (MeSH) ; Embryonic Stem Cells: metabolism (MeSH) ; Embryonic Stem Cells: cytology (MeSH) ; Chromatin: metabolism (MeSH) ; Cell Differentiation (MeSH) ; cancer ; cell fate ; epigenetics ; heterochromatin ; pluripotency ; transcription ; Histones ; Chromatin

Note: #DKFZ-MOST-Ca215#

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Database coverage:
; BIOSIS Previews ; BIOSIS Reviews Reports And Meetings ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 15 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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