Journal Article

DKFZ-2025-02620

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Predicting colorectal cancer survival by combined c-reactive protein and tumor immune score.

Gwenzi, T. (First author)DKFZ* ; Wankhede, D.DKFZ* ; Yuan, T.DKFZ* ; Bhardwaj, M.DKFZ* ; Schrotz-King, P.DKFZ* ; Anker, S. C. ; Schöttker, B.DKFZ* ; Hoffmeister, M. (Last author)DKFZ* ; Brenner, H. (Last author)DKFZ*

2025
Springer Nature [London]

Abstract: We evaluated the joint relationship of post-operative C-reactive protein (poCRP) and a tumor immune-cell-score (IS) with overall survival (OS) and CRC-specific survival (CSS) in 680 colorectal cancer (CRC) patients recruited in Germany. CRP was assessed post-surgery while IS was derived from CD3 + /CD8+ cell densities in tumor tissue. Patients were categorized into four C-Reactive protein-Immune cell Score (CRIS) groups: CRIS-1 (CRP-low/IS-high), CRIS-2 (CRP-low/IS-low), CRIS-3 (CRP-high/IS-high), and CRIS-4 (CRP-high/IS-low). Associations of CRIS with survival were assessed using Cox regression, and quantified by hazard ratios with 95% confidence intervals (HR, 95%CI). Subgroup analysis by presence of non-metastatic disease and time of blood draw in relation to adjuvant chemotherapy were conducted. After a median follow-up of 9.6 (IQR, 4.6-14.6) years, 214 (31.5%) patients died, 140 (20.6%) from CRC. Patients in CRIS-4 category had worse prognosis compared to CRIS-1 category [HR(95%CI): 2.01 (1.32-3.08) and 2.60 (1.57-4.32) for OS and CSS, respectively]. These associations were stronger for non-metastatic disease (OSHR = 2.45, CSSHR = 4.49), as well as for patients with blood collected after adjuvant chemotherapy (OSHR = 4.17, CSSHR = 6.62). Integrating post-operative systemic inflammation and tumor immune characteristics may improve prognostic stratification of patients receiving adjuvant chemotherapy for non-metastatic CRC.

Note: #EA:C070#LA:C070# / epub

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Contributing Institute(s):

1. C070 Klinische Epidemiologie der Krebsfrüherkennung (C070)
2. Primäre Krebsprävention (C120)
3. DKTK HD zentral (HD01)

Research Program(s):

1. 313 - Krebsrisikofaktoren und Prävention (POF4-313) (POF4-313)

Appears in the scientific report 2025

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