Journal Article (Letter)

DKFZ-2026-00144

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png CAR T cells targeting the glycoprotein GD2 show potent antitumor efficacy in high-risk ependymoma models.

Tallon-Cobos, A. C. ; Vazaios, K. ; Waranecki, P. ; van Hoesel, M. ; Cornel, A. ; Schwalm, B.DKFZ* ; Mack, N.DKFZ* ; de Boed, E. ; van der Lugt, J. ; Nierkens, S. ; Kool, M.DKFZ* ; Hoving, E. W. ; Metselaar, D. S.DKFZ* ; Hulleman, E.

2026
ASCJ Ann Arbor, Mich.

Abstract: Aggressive pediatric brain tumor models of ependymoma are highly sensitive to GD2-directed (CAR T) cell therapy.

Keyword(s): Ependymoma: therapy (MeSH) ; Ependymoma: immunology (MeSH) ; Ependymoma: pathology (MeSH) ; Ependymoma: genetics (MeSH) ; Humans (MeSH) ; Animals (MeSH) ; Mice (MeSH) ; Gangliosides: immunology (MeSH) ; Brain Neoplasms: therapy (MeSH) ; Brain Neoplasms: immunology (MeSH) ; Brain Neoplasms: pathology (MeSH) ; Immunotherapy, Adoptive (MeSH) ; Receptors, Chimeric Antigen: immunology (MeSH) ; Receptors, Chimeric Antigen: genetics (MeSH) ; Cell Line, Tumor (MeSH) ; Xenograft Model Antitumor Assays (MeSH) ; Disease Models, Animal (MeSH) ; Brain cancer ; Cancer immunotherapy ; Immunology ; Neuroscience ; Oncology ; Gangliosides ; ganglioside, GD2 ; Receptors, Chimeric Antigen

Note: #DKTKZFB26#

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Contributing Institute(s):

1. B062 Pädiatrische Neuroonkologie (B062)
2. DKTK HD zentral (HD01)

Research Program(s):

1. 312 - Funktionelle und strukturelle Genomforschung (POF4-312) (POF4-312)

Appears in the scientific report 2026

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Database coverage:
; ; ; ; Article Processing Charges ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; DOAJ Seal ; Ebsco Academic Search ; Essential Science Indicators ; Fees ; IF >= 15 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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