Book/Journal Article

DKFZ-2026-02558

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Analysis of Migration and Invasion in Ewing Sarcoma.

Cidre-Aranaz, F. (Last author)DKFZ*

2027
Humana Press Totowa, NJ
ISBN: 978-1-0716-5586-3 (print), 978-1-0716-5587-0 (electronic)

Abstract: Metastasis is a complex, well-orchestrated process, which includes migration from the primary tumor and invasion into secondary locations as main features. In Ewing sarcoma, metastasis is the main determinant of malignancy, with ~30% of patients presenting with metastatic disease at diagnosis. Therefore, analyzing migration and invasion in different experimental settings in vitro is key to understanding this disease. Among the variety of possible techniques to study migration, this chapter describes the methods of wound healing (migration in 2D) and transwell (migration through a porous membrane in response to a given stimulus). Additionally, this chapter includes a variation of the transwell protocol that allows the analysis of cell invasion through a gel matrix in response to a stimulus.

Keyword(s): Sarcoma, Ewing: pathology (MeSH) ; Humans (MeSH) ; Cell Movement (MeSH) ; Neoplasm Invasiveness: pathology (MeSH) ; Cell Line, Tumor (MeSH) ; Bone Neoplasms: pathology (MeSH) ; Wound Healing (MeSH) ; Cell Culture Techniques: methods (MeSH) ; Ewing sarcoma ; Invasion ; Migration ; Transwell ; Wound healing

Note: #LA:B410# / #NCTZFB26# / First Online: 16 October 2026

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Contributing Institute(s):

1. Translationale Pädiatrische Sarkomforschung (B410)
2. Koordinierungsstelle NCT Heidelberg (HD02)

Research Program(s):

1. 312 - Funktionelle und strukturelle Genomforschung (POF4-312) (POF4-312)

Appears in the scientific report 2026

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Database coverage:
; SCOPUS

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