Journal Article

DKFZ-2017-00013

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Atypical teratoid/rhabdoid tumor arising in a malignant glioma.2

Bozzai, B. ; Hasselblatt, M. ; Turányi, E. ; Frühwald, M. C. ; Siebert, R. ; Bens, S. ; Schneppenheim, R. ; Kool, M.DKFZ* ; Stelczer, G. ; Hortobágyi, T. ; Hauser, P.

2017
Wiley New York, NY

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Please use a persistent id in citations: doi:10.1002/pbc.26173

Abstract: Atypical teratoid/rhabdoid tumor (AT/RT), a highly malignant brain tumor in young children, usually arises de novo and has only rarely been described as a secondary malignancy. Here, we present a case of a child with glioblastoma, who was treated postoperatively by a combination of temozolomide, irradiation, and bevacizumab. AT/RT was diagnosed as a secondary tumor, 2.5 years following primary diagnosis. The child died 13 months after the diagnosis of AT/RT. This case demonstrates that malignant gliomas may give rise to AT/RT. It also emphasizes the diagnostic value of a repeated tumor biopsy in the recurrence setting.

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Contributing Institute(s):

1. Pädiatrische Neuroonkologie (B062)
2. DKTK Heidelberg (L101)

Research Program(s):

1. 312 - Functional and structural genomics (POF3-312) (POF3-312)

Appears in the scientific report 2017

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Database coverage:
; BIOSIS Previews ; Current Contents - Clinical Medicine ; IF < 5 ; JCR ; NCBI Molecular Biology Database ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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