Journal Article

DKFZ-2018-01567

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Crosstalk between p53 modifiers at PML bodies.

Matt, S. (First author)DKFZ* ; Hofmann, T. (Last author)DKFZ*

2018
Taylor & Francis London

Abstract: Tumor protein p53 (TP53, best known as p53), the most frequently mutated tumor suppressor in cancer, plays a central role in cell fate decisions induced by DNA damage. Regulation of p53 activity by post-translational modifications has been linked to promyelocytic leukemia nuclear bodies (PML-NBs), where p53 encounters many of its regulators. Recent evidence implies that crosstalk between p53 regulators at the PML-NB shapes post-translational modifications and function of p53.

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Contributing Institute(s):

1. Zelluläre Seneszenz (A210)

Research Program(s):

1. 311 - Signalling pathways, cell and tumor biology (POF3-311) (POF3-311)

Appears in the scientific report 2018

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Database coverage:

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