Journal Article (Review Article)

DKFZ-2019-02067

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Effects and moderators of exercise on sleep in adults with cancer: Individual patient data and aggregated meta-analyses.

Bernard, P. ; Savard, J. ; Steindorf, K.DKFZ* ; Sweegers, M. G. ; Courneya, K. S. ; Newton, R. U. ; Aaronson, N. K. ; Jacobsen, P. B. ; May, A. M. ; Galvao, D. A. ; Chinapaw, M. J. ; Stuiver, M. M. ; Griffith, K. A. ; Mesters, I. ; Knoop, H. ; Goedendorp, M. M. ; Bohus, M. ; Thorsen, L. ; Schmidt, M. E.DKFZ* ; Ulrich, C. M. ; Sonke, G. S. ; van Harten, W. ; Winters-Stone, K. M. ; Velthuis, M. J. ; Taaffe, D. R. ; van Mechelen, W. ; Kersten, M. J. ; Nollet, F. ; Wenzel, J. ; Wiskemann, J. ; Verdonck-de Leeuw, I. M. ; Brug, J. ; Buffart, L. M.

2019
Elsevier Science Amsterdam [u.a.]

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Please use a persistent id in citations: doi:10.1016/j.jpsychores.2019.109746

Abstract: To evaluate the effects of exercise interventions on sleep disturbances and sleep quality in patients with mixed cancer diagnoses, and identify demographic, clinical, and intervention-related moderators of these effects.Individual patient data (IPD) and aggregated meta-analyses of randomized controlled trials (RCTs). Using data from the Predicting OptimaL cAncer RehabIlitation and Supportive care project, IPD of 2173 adults (mean age = 54.8) with cancer from 17 RCTs were analyzed. A complementary systematic search was conducted (until November 2018) to study the overall effects and test the representativeness of analyzed IPD. Effect sizes of exercise effects on self-reported sleep outcomes were calculated for all included RCTs. Linear mixed-effect models were used to evaluate the effects of exercise on post-intervention outcome values, adjusting for baseline values. Moderator effects were studied by testing interactions for demographic, clinical and intervention-related characteristics.For all 27 eligible RCTs from the updated search, exercise interventions significantly decreased sleep disturbances in adults with cancer (g = -0.09, 95% CI [-0.16; -0.02]). No significant effect was obtained for sleep quality. RCTs included in IPD analyses constituted a representative sample of the published literature. The intervention effects on sleep disturbances were not significantly moderated by any demographic, clinical, or intervention-related factor, nor by sleep disturbances.This meta-analysis provides some evidence that, compared to control conditions, exercise interventions may improve sleep disturbances, but not sleep quality, in cancer patients, although this effect is of a small magnitude. Among the investigated variables, none was found to significantly moderate the effect of exercise interventions on sleep disturbances.

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Contributing Institute(s):

1. Bewegung, Präventionsforschung und Krebs (C110)

Research Program(s):

1. 313 - Cancer risk factors and prevention (POF3-313) (POF3-313)

Appears in the scientific report 2019

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Database coverage:
; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Social and Behavioral Sciences ; Ebsco Academic Search ; IF < 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Social Sciences Citation Index ; Web of Science Core Collection

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