Journal Article

DKFZ-2022-01144

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Reproductive factors and colorectal cancer risk: A Population-based case-control study.

Amitay, E. (First author)DKFZ* ; Niedermaier, T.DKFZ* ; Alwers, E.DKFZ* ; Chang-Claude, J.DKFZ* ; Hoffmeister, M.DKFZ* ; Brenner, H. (Last author)DKFZ*

2022
Oxford University Press Oxford

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Please use a persistent id in citations: doi:10.1093/jncics/pkac042

Abstract: Hormone-replacement therapy (HRT) is associated with lower colorectal cancer (CRC) risk among postmenopausal women. However, little is known about effects of lifetime exposure of women to varying levels of estrogen and progesterone through reproductive factors such as parity, use of oral contraceptives (OC), breastfeeding and menstruation on CRC risk.We assessed associations between reproductive factors and CRC risk among 2650 female CRC patients aged 30+ years and 2175 matched controls in a population-based study in Germany, adjusting for potential confounders by multiple logistic regression.Inverse associations with CRC risk were found for numbers of pregnancies (OR per pregnancy=0.91, 95%CI 0.86-0.97), breastfeeding for ≥12 months (OR = 0.74, 95%CI 0.61-0.90), use of either OC or HRT (OR = 0.75, 95%CI 0.64-0.87) or both (OR = 0.58, 95%CI 0.48-0.70). Similar results were found for postmenopausal women only and when adjusting for number of pregnancies and for all reproductive factors analyzed together. Breastfeeding duration of ≥ 12 months was associated with lower risk of cancer only in the proximal colon (OR = 0.58, 95%CI 0.45-0.74).Several reproductive factors were associated with lower CRC risk in women, including number of pregnancies, breastfeeding duration and use of OC and HRT. This suggests that women's exposure to female reproductive hormones play a key role in the difference in CRC risk between women and men and in site-specific CRC risk.

Keyword(s): breastfeeding ; colorectal cancer ; oral contraceptives ; pregnancy ; reproductive factors ; women

Note: #EA:C070#LA:C070#LA:C120# / 2022 Jul 1;6(4):pkac042

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Contributing Institute(s):

1. C070 Klinische Epidemiologie und Alternf. (C070)
2. C020 Epidemiologie von Krebs (C020)
3. Präventive Onkologie (C120)
4. DKTK HD zentral (HD01)

Research Program(s):

1. 313 - Krebsrisikofaktoren und Prävention (POF4-313) (POF4-313)

Appears in the scientific report 2022

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