Journal Article

DKFZ-2023-00826

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png IGSF3-mediated potassium dysregulation promotes neuronal hyperexcitability and glioma progression.

Venkataramani, V. (Last author)DKFZ*

2023
Elsevier Amsterdam

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Please use a persistent id in citations: doi:10.1016/j.trecan.2023.04.005

Abstract: Glioblastomas are incurable tumors often associated with epileptic seizures. In a recent study published in Neuron,Curry et al. demonstrated a novel function of the membrane protein IGSF3 that induces potassium dysregulation, neuronal hyperexcitability, and tumor progression. This work uncovers a novel layer of bidirectional neuron-tumor communication, further underlining the importance of comprehensively investigating neuron-tumor networks in glioblastoma.

Keyword(s): cancer neuroscience ; glioblastoma ; neuro-oncology ; neuronal hyperexcitability ; neuron–tumor networks

Note: #LA:B320# / 2023 Jun;9(6):457-458

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Contributing Institute(s):

1. KKE Neuroonkologie (B320)
2. DKTK HD zentral (HD01)

Research Program(s):

1. 312 - Funktionelle und strukturelle Genomforschung (POF4-312) (POF4-312)

Appears in the scientific report 2023

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Database coverage:
; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Essential Science Indicators ; IF >= 15 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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