Journal Article

DKFZ-2024-00060

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Toward accurate and fast velocity quantification with 3D ultrashort TE phase-contrast imaging.

Degenhardt, K. ; Schmidt, S.DKFZ* ; Aigner, C. S. ; Kratzer, F.DKFZ* ; Seiter, D. P. ; Mueller, M. ; Kolbitsch, C. ; Nagel, A.DKFZ* ; Wieben, O. ; Schaeffter, T. ; Schulz-Menger, J. ; Schmitter, S. (Last author)DKFZ*

2024
Wiley-Liss New York, NY [u.a.]

This record in other databases:  

Please use a persistent id in citations: doi:10.1002/mrm.29978

Abstract: Traditional phase-contrast MRI is affected by displacement artifacts caused by non-synchronized spatial- and velocity-encoding time points. The resulting inaccurate velocity maps can affect the accuracy of derived hemodynamic parameters. This study proposes and characterizes a 3D radial phase-contrast UTE (PC-UTE) sequence to reduce displacement artifacts. Furthermore, it investigates the displacement of a standard Cartesian flow sequence by utilizing a displacement-free synchronized-single-point-imaging MR sequence (SYNC-SPI) that requires clinically prohibitively long acquisition times.3D flow data was acquired at 3T at three different constant flow rates and varying spatial resolutions in a stenotic aorta phantom using the proposed PC-UTE, a Cartesian flow sequence, and a SYNC-SPI sequence as reference. Expected displacement artifacts were calculated from gradient timing waveforms and compared to displacement values measured in the in vitro flow experiments.The PC-UTE sequence reduces displacement and intravoxel dephasing, leading to decreased geometric distortions and signal cancellations in magnitude images, and more spatially accurate velocity quantification compared to the Cartesian flow acquisitions; errors increase with velocity and higher spatial resolution.PC-UTE MRI can measure velocity vector fields with greater accuracy than Cartesian acquisitions (although pulsatile fields were not studied) and shorter scan times than SYNC-SPI. As such, this approach is superior to traditional Cartesian 3D and 4D flow MRI when spatial misrepresentations cannot be tolerated, for example, when computational fluid dynamics simulations are compared to or combined with in vitro or in vivo measurements, or regional parameters such as wall shear stress are of interest.

Keyword(s): 4D flow MRI ; GIRF ; PC-UTE ; displacement artifact ; flow artifact ; gradient imperfections

Note: #LA:E020# / 2024 May;91(5):1994-2009

---

Contributing Institute(s):

1. E020 Med. Physik in der Radiologie (E020)

Research Program(s):

1. 315 - Bildgebung und Radioonkologie (POF4-315) (POF4-315)

Appears in the scientific report 2024

---

Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; DEAL Wiley ; Essential Science Indicators ; IF < 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

---