Journal Article

DKFZ-2026-00654

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png A photoreceptor state links aggressive brain tumors in children.

Pfister, S. (First author)DKFZ* ; Kutscher, L. (Last author)DKFZ*

2026
Cell Press Cambridge, Mass.

Abstract: In this issue of Cancer Cell, Gudenas et al. reveal that Group 3 medulloblastoma, pineoblastoma, and retinoblastoma converge on a shared tumor-associated photoreceptor signature rooted in transient developmental progenitors. This work reframes these malignancies as diseases of common developmental vulnerability and identifies shared transcriptional dependencies with potential therapeutic relevance.

Note: #EA:B062#LA:B430# / #DKTKZFB26# / #NCTZFB26# / epub / Preview

---

Contributing Institute(s):

1. B062 Pädiatrische Neuroonkologie (B062)
2. DKTK HD zentral (HD01)
3. Entwicklungsbiolog. Ursprünge pädiatrischer Krebserkrankungen (B430)
4. Koordinierungsstelle NCT Heidelberg (HD02)

Research Program(s):

1. 312 - Funktionelle und strukturelle Genomforschung (POF4-312) (POF4-312)

Appears in the scientific report 2026

---

Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 50 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

---