B430
Entwicklungsbiolog. Ursprünge pädiatrischer Krebserkrankungen
Also known as:Entwicklungsbiolog. Ursprünge pädriatischer Krebserkrankungen
| ID | I:(DE-He78)B430-20160331 |
Recent Publications
All known publications ...
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Journal Article
Sarropoulos, I. ; Sepp, M. ; Yamada, T. ; Schäfer, P. S. L. ; Trost, N. ; Schmidt, J. ; Schneider, C. ; Drummer, C. ; Mißbach, S. ; Taskiran, I. I. ; Hecker, N. ; Bravo González-Blas, C. ; Frömel, R. ; Joshi, P. K.DKFZ* ; Leushkin, E. ; Arnskötter, F.DKFZ* ; Leiss, K. ; Okonechnikov, K.DKFZ* ; Lisgo, S. ; Palkovits, M. ; Pääbo, S. ; Cardoso-Moreira, M. ; Kutscher, L.DKFZ* ; Behr, R. ; Pfister, S.DKFZ* ; Aerts, S. ; Kaessmann, H.
The evolution of gene regulation in mammalian cerebellum development.
Science / Science now 391(6784), eadw9154 (2026) [10.1126/science.adw9154]2026
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Journal Article (Review Article)
Becker, E. B. E. ; Mayer, S. ; Kutscher, L. (Last author)DKFZ*
Generating cerebellar organoids from pluripotent stem cells.
Disease models & mechanisms 19(1), dmm052478 (2026) [10.1242/dmm.052478]2026
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Journal Article
Kolodziejczak, A. (First author)DKFZ* ; Selt, F.DKFZ* ; Peterziel, H.DKFZ* ; Jamaladdin, N.DKFZ* ; Mack, N.DKFZ* ; Maaß, K.DKFZ* ; Meulenbroeks, C. ; Sigaud, R.DKFZ* ; Herold-Mende, C. ; El Damaty, A. ; Burhenne, J. ; Ohmura, S.DKFZ* ; Holland-Letz, T.DKFZ* ; Kutscher, L. M.DKFZ* ; Ernst, A.DKFZ* ; Wei, P.-C.DKFZ* ; Grünewald, T. G. P.DKFZ* ; Oehme, I.DKFZ* ; Kool, M.DKFZ* ; Jones, D. T. W.DKFZ* ; Pajtler, K. W.DKFZ* ; Kratz, C. P. ; Pfister, S. M.DKFZ* ; Witt, O.DKFZ* ; Milde, T. (Last author)DKFZ*
Preclinical drug screen identifies WEE1 inhibitor and vinca alkaloid as a combination treatment concept for Li-Fraumeni syndrome medulloblastoma.
iScience 29(2), 114564 (2026) [10.1016/j.isci.2025.114564]2026
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Journal Article
Schoof, M. ; Zheng, T. (First author)DKFZ* ; Sill, M.DKFZ* ; et al
Investigation of a global mouse methylome atlas reveals subtype-specific copy number alterations in pediatric cancer models.
Nature genetics 58(1), 143-156 (2026) [10.1038/s41588-025-02419-4]2026
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Journal Article
Ahmad, S. T. ; Li, Y. ; Garcia-Lopez, J. ; Gudenas, B. L. ; Hadley, J. ; Paul, L. ; Wu, S. C. ; Refaat, A. ; Kojic, M. ; Batts, M. ; Soliman, T. ; Pitre, A. ; Arnskötter, F.DKFZ* ; Zindy, F. ; Jones, A. ; Twarog, N. R. ; Mayasundari, A. ; Bianski, B. ; Tinkle, C. ; Shirinifard, A. ; Janke, L. ; Lu, M. ; Lewis, S. A. ; Onar-Thomas, A. ; Pfister, S. M.DKFZ* ; Gajjar, A. ; Baker, S. J. ; Roussel, M. F. ; Rankovic, Z. ; Robinson, G. W. ; Orr, B. A. ; Wainwright, B. ; Shelat, A. A. ; Waszak, S. M. ; Kutscher, L. M.DKFZ* ; Lin, H. ; Northcott, P. A.
Genetic modeling of ELP1-associated Sonic hedgehog medulloblastoma identifies MDM2 as a selective therapeutic target.
Cancer cell 43(6), 1141-1158.e11 (2025) [10.1016/j.ccell.2025.04.014]2025
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Journal Article
Okonechnikov, K. (First author)DKFZ* ; Joshi, P. K. (First author)DKFZ* ; Körber, V. (First author)DKFZ* ; Rademacher, A.DKFZ* ; Bortolomeazzi, M.DKFZ* ; Mallm, J.-P.DKFZ* ; Vaillant, J.DKFZ* ; da Silva, P. B. G.DKFZ* ; Statz, B.DKFZ* ; Sepp, M. ; Sarropoulos, I. ; Yamada, T. ; Wittmann, A.DKFZ* ; Schramm, K.DKFZ* ; Blattner-Johnson, M.DKFZ* ; Fiesel, P.DKFZ* ; Jones, B.DKFZ* ; Jäger, N.DKFZ* ; Milde, T.DKFZ* ; Pajtler, K.DKFZ* ; van Tilburg, C. M.DKFZ* ; Witt, O.DKFZ* ; Bochennek, K. ; Weber, K. J.DKFZ* ; Nonnenmacher, L. ; Reimann, C. ; Ghasemi, D. R.DKFZ* ; Schüller, U. ; Mynarek, M. ; Rutkowski, S. ; Jones, D.DKFZ* ; Korshunov, A.DKFZ* ; Rippe, K.DKFZ* ; Westermann, F.DKFZ* ; Thongjuea, S.DKFZ* ; Höfer, T.DKFZ* ; Kaessmann, H.DKFZ* ; Kutscher, L. (Last author)DKFZ* ; Pfister, S. (Last author)DKFZ*
Oncogene aberrations drive medulloblastoma progression, not initiation.
Nature 642(8069), 1062-1072 (2025) [10.1038/s41586-025-08973-5]2025
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Dissertation / PhD Thesis
Spänig, L.DKFZ*
Spatial and temporal localization of unipolar brush cells in mice and humans using multiplexing immunofluorescence imaging approaches
Dissertation, University of Heidelberg, 2025
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Journal Article
Kutscher, L. (First author)DKFZ* ; Aprile, D. ; Bayin, N. S. ; Becker, E. B. E. ; Cerrato, V. ; Turrini, G. ; Coolen, M. ; Cantagrel, V. ; Durand, B. C. ; Evans Ii, M. K. ; Haldipur, P. ; Millen, K. J. ; Yeung, J. ; Goldowitz, D. ; Hatten, M. E. ; Joyner, A. L. ; Kebschull, J. M. ; Li, J. Y. H. ; Quadrato, G. ; Schmidt, C. ; Sepp, M. ; Silva, T. P. ; Testa, G. ; Tiberi, L. ; Mayer, S.
Conference Report: Cerebellar Development and Disease at Single-Cell Resolution.
The cerebellum 24(4), 109 (2025) [10.1007/s12311-025-01864-5]2025
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Preprint
Joshi, P. K. (First author)DKFZ* ; Stelzer, T.DKFZ* ; Okonechnikov, K.DKFZ* ; Sarropoulos, I. ; Sepp, M. ; Pour-Jamnani, M. V.DKFZ* ; Rademacher, A.DKFZ* ; Yamada-Saito, T. ; Schneider, C. ; Schmidt, J. ; Schäfer, P. ; Leiss, K. ; Bortolomeazzi, M.DKFZ* ; Mallm, J.-P.DKFZ* ; da Silva, P. B. G.DKFZ* ; Statz, B.DKFZ* ; Wittmann, A.DKFZ* ; Schramm, K.DKFZ* ; Blattner-Johnson, M.DKFZ* ; Fiesel, P.DKFZ* ; Jones, B.DKFZ* ; Milde, T.DKFZ* ; Pajtler, K.DKFZ* ; van Tilburg, C. M.DKFZ* ; Witt, O.DKFZ* ; Rippe, K.DKFZ* ; Korshunov, A.DKFZ* ; Jones, D. T. W.DKFZ* ; Hovestadt, V. ; Northcott, P. A. ; Thongjuea, S.DKFZ* ; Jäger, N.DKFZ* ; Kaessmann, H. ; Pfister, S. M.DKFZ* ; Kutscher, L. (Last author)DKFZ*
Gene regulatory network landscape of Group 3/4 medulloblastoma
[doi.org/10.1101/2024.02.09.579680]
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Preprint
Okonechnikov, K. (First author)DKFZ* ; Joshi, P. K.DKFZ* ; Körber, V.DKFZ* ; Rademacher, A.DKFZ* ; Bortolomeazzi, M.DKFZ* ; Mallm, J.-P.DKFZ* ; da Silva, P. B. G.DKFZ* ; Statz, B.DKFZ* ; Sepp, M. ; Sarropoulos, I. ; Yamada-Saito, T. ; Vaillant, J.DKFZ* ; Wittmann, A.DKFZ* ; Schramm, K.DKFZ* ; Blattner-Johnson, M.DKFZ* ; Fiesel, P.DKFZ* ; Jones, B.DKFZ* ; Milde, T.DKFZ* ; Pajtler, K.DKFZ* ; van Tilburg, C. M.DKFZ* ; Witt, O.DKFZ* ; Bochennek, K. ; Weber, K. J. ; Nonnenmacher, L. ; Reimann, C. ; Schüller, U. ; Mynarek, M. ; Rutkowski, S. ; Jones, D. T. W.DKFZ* ; Korshunov, A.DKFZ* ; Rippe, K.DKFZ* ; Westermann, F.DKFZ* ; Thongjuea, S.DKFZ* ; Höfer, T.DKFZ* ; Kaessmann, H. ; Kutscher, L.DKFZ* ; Pfister, S. (Last author)DKFZ*
Medulloblastoma oncogene aberrations are not involved in tumor initiation, but essential for disease progression and therapy resistance
[doi.org/10.1101/2024.02.09.579690]
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All known publications ...
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