Journal Article (Review Article)

DKFZ-2024-00794

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png The enchanting canvas of CAR technology: Unveiling its wonders in non-neoplastic diseases.

Shu, J. ; Xie, W. ; Chen, Z. ; Offringa, R.DKFZ* ; Hu, Y. ; Mei, H.

2024
Elsevier Amsterdam

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Please use a persistent id in citations: doi:10.1016/j.medj.2024.03.016

Abstract: Chimeric antigen receptor (CAR) T cells have made a groundbreaking advancement in personalized immunotherapy and achieved widespread success in hematological malignancies. As CAR technology continues to evolve, numerous studies have unveiled its potential far beyond the realm of oncology. This review focuses on the current applications of CAR-based cellular platforms in non-neoplastic indications, such as autoimmune, infectious, fibrotic, and cellular senescence-associated diseases. Furthermore, we delve into the utilization of CARs in non-T cell populations such as natural killer (NK) cells and macrophages, highlighting their therapeutic potential in non-neoplastic conditions and offering the potential for targeted, personalized therapies to improve patient outcomes and enhanced quality of life.

Keyword(s): CAR ; CAR macrophage ; CAR-NK ; autoimmune diseases ; cellular senescence ; fibrotic diseases ; infectious diseases

Note: 2024 Jun 14;5(6):495-529

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Contributing Institute(s):

1. Molekulare Grundlagen Gastrointestinaler Tumoren (D200)

Research Program(s):

1. 314 - Immunologie und Krebs (POF4-314) (POF4-314)

Appears in the scientific report 2024

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Database coverage:
; Clarivate Analytics Master Journal List ; Emerging Sources Citation Index ; IF >= 15 ; JCR ; SCOPUS ; Web of Science Core Collection

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