Journal Article

DKFZ-2026-01074

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Protocol for natural and biomedical image processing in the hypercomplex domain using the 2D orthogonal planes split.

Valous, N. (First author)DKFZ* ; Hitzer, E. ; Duse, D.DKFZ* ; Moraleda, R. R.DKFZ* ; Popp, F.DKFZ* ; Suarez-Carmona, M.DKFZ* ; Berthel, A.DKFZ* ; Papageorgiou, I. ; Fremd, C.DKFZ* ; Rölle, A.DKFZ* ; Westhoff, C. C. ; Lenoir, B.DKFZ* ; Halama, N.DKFZ* ; Zörnig, I.DKFZ* ; Jäger, D. (Last author)DKFZ*

2026
Cell Press Cambridge, MA

Abstract: We present a protocol for processing natural and biomedical images in the hypercomplex domain. First, the protocol converts images into quaternion matrices. It then applies the 2D orthogonal planes split to perform re-colorization, de-colorization, contrast enhancement, re-staining, and stain separation. Finally, it uses post-processing operations to generate the output. The resulting output supports qualitative assessment and downstream processing in computer vision and computational pathology pipelines. For details and literature comparisons, please refer to Valous et al.1.

Keyword(s): Computer sciences ; Health Sciences ; Systems biology

Note: #EA:D120#LA:D120# / #NCTZFB26#

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Contributing Institute(s):

1. Angewandte Tumor-Immunität (D120)
2. Koordinierungsstelle NCT Heidelberg (HD02)
3. Angewandte Bioinformatik (B330)
4. Translationale Immuntherapie (D196)
5. B060 Molekulare Genetik (B060)
6. NWG Systemimmunologie und Einzelzell-Biologie (D260)

Research Program(s):

1. 314 - Immunologie und Krebs (POF4-314) (POF4-314)

Appears in the scientific report 2026

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Database coverage:
; ; Article Processing Charges ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; DOAJ Seal ; Emerging Sources Citation Index ; Fees ; SCOPUS ; Web of Science Core Collection

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