Journal Article (Review Article)

DKFZ-2024-00947

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Cilia as Wnt signaling organelles.

Niehrs, C. (First author)DKFZ* ; Da Silva, F.DKFZ* ; Seidl, C. (Last author)DKFZ*

2025
Elsevier Science Amsterdam [u.a.]

This record in other databases:  

Please use a persistent id in citations: doi:10.1016/j.tcb.2024.04.001

Abstract: Cilia and Wnt signaling have a complex relationship, wherein Wnt regulates cilia and, conversely, cilia may affect Wnt signaling. Recently, it was shown that Wnt receptors are present in flagella, primary cilia, and multicilia, where they transmit an intraciliary signal that is independent of β-catenin. Intraciliary Wnt signaling promotes ciliogenesis, affecting male fertility, adipogenesis, and mucociliary clearance. Wnt also stimulates the beating of motile cilia, highlighting that these nanomotors, too, are chemosensory. Intraciliary Wnt signaling employs a Wnt-protein phosphatase 1 (PP1) signaling axis, involving the canonical Wnt pathway's inhibition of glycogen synthase kinase 3 (GSK3) to repress PP1 activity. Collectively, these findings support that cilia are Wnt signaling organelles, with implications for ciliopathies and cancer.

Keyword(s): GSK3 ; Wnt ; cilia ; ciliary signaling ; ciliogenesis

Note: DKFZ-ZMBH Alliance / Volume 35, Issue 1, January 2025, Pages 24-32 / #EA:A050#LA:A050#

---

Contributing Institute(s):

1. A050 Molekulare Embryologie (A050)

Research Program(s):

1. 311 - Zellbiologie und Tumorbiologie (POF4-311) (POF4-311)

Appears in the scientific report 2024

---

Database coverage:
; BIOSIS Previews ; BIOSIS Reviews Reports And Meetings ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 15 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

---