Journal Article

DKFZ-2024-01307

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Radiotherapy for Recurrent Medulloblastoma in Children and Adolescents: Survival after Re-Irradiation and First-Time Irradiation.

Adolph, J. E. ; Fleischhack, G. ; Tschirner, S. ; Rink, L. ; Dittes, C. ; Mikasch, R. ; Dammann, P. ; Mynarek, M. ; Obrecht-Sturm, D. ; Rutkowski, S. ; Bison, B. ; Warmuth-Metz, M. ; Pietsch, T. ; Pfister, S.DKFZ* ; Pajtler, K.DKFZ* ; Milde, T.DKFZ* ; Kortmann, R.-D. ; Dietzsch, S. ; Timmermann, B. ; Tippelt, S. ; HIT-Network, G. G. (Collaboration Author)

2024
MDPI Basel

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Please use a persistent id in citations: doi:10.3390/cancers16111955

Abstract: Radiotherapy (RT) involving craniospinal irradiation (CSI) is important in the initial treatment of medulloblastoma. At recurrence, the re-irradiation options are limited and associated with severe side-effects.For pre-irradiated patients, patients with re-irradiation (RT2) were matched by sex, histology, time to recurrence, disease status and treatment at recurrence to patients without RT2.A total of 42 pre-irradiated patients with RT2 were matched to 42 pre-irradiated controls without RT2. RT2 improved the median PFS [21.0 (CI: 15.7-28.7) vs. 12.0 (CI: 8.1-21.0) months] and OS [31.5 (CI: 27.6-64.8) vs. 20.0 (CI: 14.0-36.7) months]. Concerning long-term survival after ten years, RT2 only lead to small improvements in OS [8% (CI: 1.4-45.3) vs. 0%]. RT2 improved survival most without (re)-resection [PFS: 17.5 (CI: 9.7-41.5) vs. 8.0 (CI: 6.6-12.2)/OS: 31.5 (CI: 27.6-NA) vs. 13.3 (CI: 8.1-20.1) months]. In the RT-naïve patients, CSI at recurrence improved their median PFS [25.0 (CI: 16.8-60.6) vs. 6.6 (CI: 1.5-NA) months] and OS [40.2 (CI: 18.7-NA) vs. 12.4 (CI: 4.4-NA) months].RT2 could improve the median survival in a matched cohort but offered little benefit regarding long-term survival. In RT-naïve patients, CSI greatly improved their median and long-term survival.

Keyword(s): medulloblastoma ; radiotherapy ; re-irradiation ; recurrence ; resection

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Contributing Institute(s):

1. B062 Pädiatrische Neuroonkologie (B062)
2. KKE Pädiatrische Onkologie (B310)
3. DKTK HD zentral (HD01)

Research Program(s):

1. 312 - Funktionelle und strukturelle Genomforschung (POF4-312) (POF4-312)

Appears in the scientific report 2024

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Database coverage:
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