Journal Article

DKFZ-2024-01441

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Long-range inhibition from prelimbic to cingulate areas of the medial prefrontal cortex enhances network activity and response execution.

Utashiro, N. (First author)DKFZ* ; MacLaren, D. (First author)DKFZ* ; Liu, Y.-C. (First author)DKFZ* ; Yaqubi, K.DKFZ* ; Wojak, B.DKFZ* ; Monyer, H. (Last author)DKFZ*

2024
Nature Publishing Group UK [London]

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Please use a persistent id in citations: doi:10.1038/s41467-024-50055-z

Abstract: It is well established that the medial prefrontal cortex (mPFC) exerts top-down control of many behaviors, but little is known regarding how cross-talk between distinct areas of the mPFC influences top-down signaling. We performed virus-mediated tracing and functional studies in male mice, homing in on GABAergic projections whose axons are located mainly in layer 1 and that connect two areas of the mPFC, namely the prelimbic area (PrL) with the cingulate area 1 and 2 (Cg1/2). We revealed the identity of the targeted neurons that comprise two distinct types of layer 1 GABAergic interneurons, namely single-bouquet cells (SBCs) and neurogliaform cells (NGFs), and propose that this connectivity links GABAergic projection neurons with cortical canonical circuits. In vitro electrophysiological and in vivo calcium imaging studies support the notion that the GABAergic projection neurons from the PrL to the Cg1/2 exert a crucial role in regulating the activity in the target area by disinhibiting layer 5 output neurons. Finally, we demonstrated that recruitment of these projections affects impulsivity and mechanical responsiveness, behaviors which are known to be modulated by Cg1/2 activity.

Keyword(s): Animals (MeSH) ; Prefrontal Cortex: physiology (MeSH) ; Prefrontal Cortex: cytology (MeSH) ; Male (MeSH) ; Gyrus Cinguli: physiology (MeSH) ; Gyrus Cinguli: cytology (MeSH) ; GABAergic Neurons: metabolism (MeSH) ; GABAergic Neurons: physiology (MeSH) ; Mice (MeSH) ; Interneurons: physiology (MeSH) ; Mice, Inbred C57BL (MeSH) ; Nerve Net: physiology (MeSH) ; Neural Pathways: physiology (MeSH)

Note: #EA:A230#LA:A230#

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Contributing Institute(s):

1. A230 Klinische Neurobiologie (A230)

Research Program(s):

1. 311 - Zellbiologie und Tumorbiologie (POF4-311) (POF4-311)

Appears in the scientific report 2024

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